{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:34:33Z","timestamp":1776432873167,"version":"3.51.2"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071964"],"award-info":[{"award-number":["82071964"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202203"],"award-info":[{"award-number":["82202203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["GWVI\u201011. 2\u2010YQ51"],"award-info":[{"award-number":["GWVI\u201011. 2\u2010YQ51"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008838","name":"Shanghai Municipal Commission of Economy and Informatization","doi-asserted-by":"publisher","award":["23SHS06500\u201004"],"award-info":[{"award-number":["23SHS06500\u201004"]}],"id":[{"id":"10.13039\/501100008838","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gut microbiota has a close connection to different thyroid disorders, yet research on its links to subclinical hypothyroidism (SCH) remains limited and insufficient. In this study, we explored the potential relationship between the gut microbiota and SCH, as well as dyslipidemia in SCH mice. The SCH mouse model was induced using methimazole. The composition of the gut microbiota from mice was then analyzed through 16S rRNA gene sequencing technology. An antibiotic disruption experiment was used to assess how gut microbiota imbalance impacts thyroid function. The SCH mouse models were constructed and accompanied by significant dyslipidemia. The results revealed no significant differences in the\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    to\n                    <jats:italic>Bacteroidota<\/jats:italic>\n                    ratio or \u03b1\u2010diversity in gut microbiota from SCH and control mice, and in \u03b2\u2010diversity, there was a noticeable but small difference between the groups. 14 differential genera between the two groups identified through LEfSe analysis were significantly correlated with serum lipid levels. Furthermore, the results of the antibiotic disruption experiment demonstrated that gut microbiota imbalance exacerbated the hypothyroidism in mice. The present results suggest that subclinical hypothyroidism has not yet caused significant changes in gut microbiota homeostasis, but gut microbiota plays an important role in regulating thyroid function and is closely associated with dyslipidemia in SCH. This study could help understand the relationship between gut microbiota and SCH, and offer new perspectives on dyslipidemia management in SCH.\n                  <\/jats:p>","DOI":"10.1096\/fj.202402289rr","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:01:44Z","timestamp":1741694504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gut microbiota alteration was related to subclinical hypothyroidism and dyslipidemia in mice"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-7359","authenticated-orcid":false,"given":"Ru","family":"Wang","sequence":"first","affiliation":[{"name":"Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8517-870X","authenticated-orcid":false,"given":"Xiaqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3024-2137","authenticated-orcid":false,"given":"Haidong","family":"Cai","sequence":"additional","affiliation":[{"name":"Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0913-4510","authenticated-orcid":false,"given":"Ganghua","family":"Lu","sequence":"additional","affiliation":[{"name":"Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1782-1628","authenticated-orcid":false,"given":"Dingwei","family":"Gao","sequence":"additional","affiliation":[{"name":"Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4743-352X","authenticated-orcid":false,"given":"Mengyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5342-5140","authenticated-orcid":false,"given":"Li","family":"Chai","sequence":"additional","affiliation":[{"name":"Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-6616","authenticated-orcid":false,"given":"Wanwan","family":"Yi","sequence":"additional","affiliation":[{"name":"Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1400-043X","authenticated-orcid":false,"given":"Zhongwei","family":"Lv","sequence":"additional","affiliation":[{"name":"Clinical Nuclear Medicine Center, Imaging Clinical Medical Center, Institute of Nuclear Medicine, Institute of Clinical Mass Spectrometry Applied Research Center, Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai China"},{"name":"Shanghai Public Health Clinical Center Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8182"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.86a.17053"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.9052"},{"issue":"4","key":"e_1_2_10_6_1","first-page":"428","article-title":"Lipid profile in mild subclinical hypothyroidism: systematic review and meta\u2010analysis","volume":"46","author":"Treister\u2010Goltzman Y","year":"2021","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2022.01.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5216945"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2019.02.011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-4-200002150-00004"},{"issue":"3","key":"e_1_2_10_11_1","first-page":"1108","article-title":"Microbiota\u2010gut\u2010brain Axis dysregulation in Alzheimer's disease: multi\u2010pathway effects and therapeutic potential","volume":"15","author":"Qu L","year":"2024","journal-title":"Aging Dis"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0433-9"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600266"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2022.0491"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061769"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.24151"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0395"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1831-x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00495"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.794170"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201903091RR"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-019-09512-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11080531"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00886G"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsec\/fiy045"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010255"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041206"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2024.109831"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.122"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00395-21"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0193"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-123"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082679"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20200475"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1656"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2022.2064725"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.08.101"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.834674"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2021.110360"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1012028"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2057778"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02517-22"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2014.05.005"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-023-10068-4"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.01.053"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1094095"},{"issue":"6","key":"e_1_2_10_47_1","first-page":"E966","article-title":"Binding and degradation of 3,5,3\u2032\u2010triiodothyronine and thyroxine by rat intestinal bacteria","volume":"264","author":"DiStefano JJ","year":"1993","journal-title":"Am J Phys"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-125-6-2822"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00929-2"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00316"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00952-4"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202402289RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:47:49Z","timestamp":1761673669000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202402289RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3,15]]}},"alternative-id":["10.1096\/fj.202402289RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202402289rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"2024-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70445"}}