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Part of the inflammatory response to O\n                    <jats:sub>3<\/jats:sub>\n                    includes altered expression of formyl peptide receptor 2 (ALX\/FPR2), a G protein\u2010coupled receptor expressed primarily in immune cells. ALX\/FPR2 is considered either anti\u2010inflammatory\/proresolving or proinflammatory depending on its ligands, which include lipoxin A4 or serum amyloid A (SAA). While the anti\u2010inflammatory\/proresolving lipoxin A4 ligand has been well studied, there remains a significant knowledge gap in the interaction between proinflammatory SAA and ALX\/FPR2. To date, SAA has been shown to increase neutrophil recruitment through ALX\/FPR2 and is increased systemically after O\n                    <jats:sub>3<\/jats:sub>\n                    exposure. However, it is unclear if pulmonary SAA signals through ALX\/FPR2 during the O\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced inflammatory response. We hypothesized that ALX\/FPR2\u2010SAA signaling is required to initiate neutrophil recruitment to the lungs following O\n                    <jats:sub>3<\/jats:sub>\n                    exposure. To test this hypothesis, ALX\/FPR2 wild type (FPR2\n                    <jats:sup>+\/+<\/jats:sup>\n                    ) or knockout (FPR2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice were exposed to filtered air (FA) or 1\u2009ppm O\n                    <jats:sub>3<\/jats:sub>\n                    for 3\u2009h. Pulmonary inflammation was assessed 6, 24, and 48\u2009h following O\n                    <jats:sub>3<\/jats:sub>\n                    exposure. FPR2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice exhibited impaired neutrophil recruitment at 6 and 24\u2009h after O\n                    <jats:sub>3<\/jats:sub>\n                    exposure. In addition, FPR2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mouse pulmonary SAA expression was significantly increased after O\n                    <jats:sub>3<\/jats:sub>\n                    exposure compared to FPR2\n                    <jats:sup>+\/+<\/jats:sup>\n                    mice. FPR2\n                    <jats:sup>+\/+<\/jats:sup>\n                    mice dosed with SAA via oropharyngeal aspiration had increased pulmonary neutrophils, while neutrophils were not increased in FPR2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Taken together, these data indicate that ALX\/FPR2 may contribute to SAA\u2010induced pulmonary neutrophilia following O\n                    <jats:sub>3<\/jats:sub>\n                    exposure.\n                  <\/jats:p>","DOI":"10.1096\/fj.202402865r","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T03:34:51Z","timestamp":1748316891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>ALX<\/scp>\n                    \/\n                    <scp>FPR2<\/scp>\n                    Contributes to Serum Amyloid A\u2010Induced Lung Neutrophil Recruitment Following Acute Ozone Exposure"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-6360","authenticated-orcid":false,"given":"Michael J.","family":"Yaeger","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6406-383X","authenticated-orcid":false,"given":"Tyson","family":"Ngatikaura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5455-2555","authenticated-orcid":false,"given":"Natali","family":"Zecchino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-8446","authenticated-orcid":false,"given":"Katelyn","family":"Dunigan\u2010Russell","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6088-9217","authenticated-orcid":false,"given":"Hannah B.","family":"Lovins","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2013-4249","authenticated-orcid":false,"given":"Evangeline","family":"Schott","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1100-1786","authenticated-orcid":false,"given":"Grace","family":"Hutton","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4325-4515","authenticated-orcid":false,"given":"Brett","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4384-8354","authenticated-orcid":false,"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"Nicholas School of the Environment Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3759-6672","authenticated-orcid":false,"given":"Junfeng (Jim)","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nicholas School of the Environment Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7314-4265","authenticated-orcid":false,"given":"Samuel J.","family":"Cochran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1729-6616","authenticated-orcid":false,"given":"Rafia","family":"Virk","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Gillings School of Global Public Health and School of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4218-6507","authenticated-orcid":false,"given":"R. 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