{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:03:07Z","timestamp":1783422187858,"version":"3.54.6"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371697"],"award-info":[{"award-number":["82371697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971410"],"award-info":[{"award-number":["81971410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gestational Diabetes Mellitus (GDM) is the most frequent complication during pregnancy. Pharmacological interventions, such as peptide drugs that focused on improving the insulin sensitivity might be promising in the prevention and treatment of GDM. In this study, we aimed to investigate the role and mechanism of a novel peptide, named AGDMP1 (Anti\u2010GDM peptide 1), which we previously identified lower in the serum of GDM patients using mass spectrometry, on the adipose insulin resistance in GDM. We found that AGDMP1 had a high affinity for adipose tissues\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    . AGDMP1 markedly improved glucose homeostasis and insulin resistance in GDM mice. This was associated with reduced inflammation and upregulated AKT\/GLUT4 signaling pathway in white adipose tissue.\n                    <jats:italic>In\u00a0vitro<\/jats:italic>\n                    , AGDMP1 could increase glucose uptake and insulin sensitivity of adipocytes by activating the IRS\u20101\/AKT\/GLUT4 signaling pathway under basal, insulin\u2010stimulated, and insulin\u2010resistant conditions, respectively. Mechanistically, we found that AGDMP1 could bind to HSP60 to dampen its effects on AKT signaling and pro\u2010inflammatory response, which was reversed in the present of recombinant HSP60 protein. AGDMP1 ameliorated adipose insulin resistance and inflammation by targeting HSP60 and activating the IRS\u20101\/AKT\/GLUT4 signaling pathway. These data supported AGDMP1 with therapeutic potential in GDM and associated pathologies.\n                  <\/jats:p>","DOI":"10.1096\/fj.202402886r","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T09:34:52Z","timestamp":1737711292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>AGDMP1<\/scp>\n                    alleviates insulin resistance by modulating heat shock protein 60\u2010mediated\n                    <scp>IRS<\/scp>\n                    \u20101\/\n                    <scp>AKT<\/scp>\n                    \/\n                    <scp>GLUT4<\/scp>\n                    pathway and adipose inflammation: A potential therapeutic peptide for gestational diabetes mellitus"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1203-5637","authenticated-orcid":false,"given":"Shanshan","family":"Wang","sequence":"first","affiliation":[{"name":"Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center Nanjing Medical University  Changzhou Jiangsu China"},{"name":"Changzhou Key Laboratory of Maternal and Child Health Medicine  Changzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6632-1866","authenticated-orcid":false,"given":"Yuting","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0269-933X","authenticated-orcid":false,"given":"Shiman","family":"Hu","sequence":"additional","affiliation":[{"name":"Changzhou 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