{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:41:40Z","timestamp":1791589300579,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH262"],"award-info":[{"award-number":["ZR2021MH262"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH133"],"award-info":[{"award-number":["ZR2023QH133"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Preeclampsia (PE) is associated with significant maternal and fetal morbidity and mortality, with placental trophoblast dysfunction playing a central role in its pathogenesis. Autophagic imbalance impacts trophoblast function, and the regulatory role of formyl\u2010peptide receptor 2 (FPR2) in trophoblast autophagy and placental function requires further investigation. We used the HTR8\/SVneo cell line and\n                    <jats:italic>Fpr2<\/jats:italic>\n                    knockout mice to explore the role of FPR2 in trophoblast function. The expression of FPR2 and autophagy levels were elevated in PE patients and models.\n                    <jats:italic>FPR2<\/jats:italic>\n                    knockdown reversed the H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced inhibition of trophoblast function and downregulated autophagy\u2010related proteins. H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    activated the PI3K\/AKT\/mTOR pathway, but this activation was reduced by\n                    <jats:italic>FPR2<\/jats:italic>\n                    knockdown or 3\u2010MA pretreatment. We demonstrate that FPR2 regulates trophoblast autophagy through the PI3K\/AKT\/mTOR signaling pathway, contributing to the development of PE. These findings may offer new insights into the prevention and treatment of PE.\n                  <\/jats:p>","DOI":"10.1096\/fj.202402938rr","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T02:44:16Z","timestamp":1749177856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of FPR2 on the Regulation of Trophoblast Autophagy via the PI3K\/AKT\/mTOR Signaling Pathway in Preeclampsia"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3857-2835","authenticated-orcid":false,"given":"Ning","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Maternal 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