{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:18:55Z","timestamp":1790360335839,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001673","name":"Fondation J\u00e9r\u00f4me Lejeune","doi-asserted-by":"publisher","award":["2020b cycle\u2010Project 2001"],"award-info":[{"award-number":["2020b cycle\u2010Project 2001"]}],"id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001673","name":"Fondation J\u00e9r\u00f4me Lejeune","doi-asserted-by":"publisher","award":["JLF1801"],"award-info":[{"award-number":["JLF1801"]}],"id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001673","name":"Fondation J\u00e9r\u00f4me Lejeune","doi-asserted-by":"publisher","award":["No.55(2023Edition)"],"award-info":[{"award-number":["No.55(2023Edition)"]}],"id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2024 FI\u20103 00160"],"award-info":[{"award-number":["2024 FI\u20103 00160"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2023 FI\u20102 00160"],"award-info":[{"award-number":["2023 FI\u20102 00160"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/01126"],"award-info":[{"award-number":["PI14\/01126"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01019"],"award-info":[{"award-number":["PI17\/01019"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00836"],"award-info":[{"award-number":["PI20\/00836"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AG056850\u201001A1"],"award-info":[{"award-number":["1R01AG056850\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG056974"],"award-info":[{"award-number":["R21AG056974"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG061566"],"award-info":[{"award-number":["R01AG061566"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1RF1AG080769\u201001"],"award-info":[{"award-number":["1RF1AG080769\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["UK\u201023\u2010971107"],"award-info":[{"award-number":["UK\u201023\u2010971107"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2021 SGR00706"],"award-info":[{"award-number":["2021 SGR00706"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2021SGR01396"],"award-info":[{"award-number":["2021SGR01396"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Down syndrome (DS), caused by trisomy 21, is associated with an increased risk of Alzheimer's disease (AD) and obstructive sleep apnea (OSA). Traditional diagnostic methods for AD and OSA, like cerebrospinal fluid analysis and polysomnography, are invasive and challenging for people with DS. In this study, we assessed whether facial morphology could be used as a potential noninvasive biomarker for these conditions in both DS and the general population. We performed a comprehensive 3D analysis of facial shape variation by registering the 3D coordinates of 21 landmarks on facial models extracted from magnetic resonance images of 131 individuals with DS and 216 euploid (EU) adult controls, including AD and OSA cases. Procrustes ANOVA and MANOVA quantified shape variation by sex, age, and facial size, while geometric morphometrics assessed diagnostic group differences. Significant facial shape differences were observed between the DS and EU groups, indicating sex\u2010dependent differences and altered age\u2010related changes in DS, particularly in females. Facial shape correlated with the amyloid beta ratio (A\u03b21\u201042\/A\u03b21\u201040), a key AD biomarker. In DS, facial shape differences by AD diagnosis were not significant after adjusting for age and facial size, but significant shape differences were detected in the EU population. For OSA, facial shape correlated with the apnea\u2013hypopnea index (AHI), and DS individuals with severe OSA showed distinct facial morphology compared with those without OSA, suggesting an association between facial shape and sleep respiratory disturbances. These results highlight the potential of facial morphology as a noninvasive biomarker for AD and OSA detection and management.<\/jats:p>","DOI":"10.1096\/fj.202403009r","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T18:38:08Z","timestamp":1742841488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Potential of facial biomarkers for Alzheimer's disease and obstructive sleep apnea in Down syndrome and general population"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9799-0252","authenticated-orcid":false,"given":"L. M.","family":"Echeverry\u2010Quiceno","sequence":"first","affiliation":[{"name":"Departament de Biologia Evolutiva, Ecologia i Ci\u00e8ncies Ambientals (BEECA), Facultat de Biologia Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9980-0208","authenticated-orcid":false,"given":"S.","family":"Llambrich","sequence":"additional","affiliation":[{"name":"Departament de Biologia Evolutiva, Ecologia i Ci\u00e8ncies Ambientals (BEECA), Facultat de Biologia Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-8744","authenticated-orcid":false,"given":"\u00c1.","family":"Heredia\u2010Lid\u00f3n","sequence":"additional","affiliation":[{"name":"HER \u2010 Human\u2010Environment Research Group La Salle \u2010 Universitat Ramon Llull  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8031-2319","authenticated-orcid":false,"given":"S.","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Multidisciplinary Sleep Unit \u2010 Respiratory Department, Hospital de la Santa Creu i Sant Pau Biomedical Research Institute Sant Pau, Institut de Recerca Sant Pau \u2010, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Memory Unit, Department of Neurology, Institut de Recerca Sant Pau \u2010 Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-292X","authenticated-orcid":false,"given":"M.","family":"Rozalem\u2010Aranha","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut de Recerca Sant Pau \u2010 Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"},{"name":"Neuroradiology Section, Department of Radiology, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0206-1317","authenticated-orcid":false,"given":"P.","family":"Inampudi","sequence":"additional","affiliation":[{"name":"Columbia University College of Dental Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0660-9613","authenticated-orcid":false,"given":"Y.","family":"Heuz\u00e9","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, Minist\u00e8re de la Culture, PACEA, UMR 5199  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6209-3033","authenticated-orcid":false,"given":"X.","family":"Sevillano","sequence":"additional","affiliation":[{"name":"HER \u2010 Human\u2010Environment Research Group La Salle \u2010 Universitat Ramon Llull  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1340-638X","authenticated-orcid":false,"given":"J.","family":"Fortea","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut de Recerca Sant Pau \u2010 Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-2123","authenticated-orcid":false,"given":"N.","family":"Mart\u00ednez\u2010Abad\u00edas","sequence":"additional","affiliation":[{"name":"Departament de Biologia Evolutiva, Ecologia i Ci\u00e8ncies Ambientals (BEECA), Facultat de Biologia Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0012162204000441"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020050"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2002.620506.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/IYC.0b013e3182002cfe"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12026"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.05.003"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7382"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz061"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27541"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.22255"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83757-1"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.10.003"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14391-3"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161047"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201704-0704OC"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009315"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz048"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00078"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30285-0"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00245-3"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2018.1439743"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-33374-x"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-0845-y"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0279-0"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-01010-x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/s20113171"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22054"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2024.116027"},{"issue":"19","key":"e_1_2_13_30_1","first-page":"5","article-title":"Craniofacial embryology and postnatal development of relevant parts of the upper respiratory system","volume":"8","author":"Halewyck S","year":"2012","journal-title":"B\u2010ENT"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2015.09.001"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202545"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10070862"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep\/32.1.37"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13081196"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2020.05.026"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12653"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-95022019000100338"},{"key":"e_1_2_13_39_1","first-page":"568","article-title":"Essentials of facial growth","volume":"110","author":"Enlow DH","year":"1996","journal-title":"Am J Orth Dent Orth"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20317"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-019-0213-9"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511573064"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119072492"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.24531"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.33588\/rn.5708.2013259"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"e_1_2_13_47_1","unstructured":"Heredia\u2010Lid\u00f3nA Echeverry\u2010QuicenoLM Gonz\u00e1lezA et\u00a0al.BioFace3D: a fully automatic pipeline for facial biomarkers extraction of 3D face reconstructions segmented from MRI. arXiv 2410.007112024. doi:10.48550\/arXiv.2410.00711"},{"key":"e_1_2_13_48_1","doi-asserted-by":"crossref","unstructured":"Heredia\u2010Lid\u00f3nA Garc\u00eda\u2010MascarellC Echeverry\u2010QuicenoLM et\u00a0al.A critical comparison between template\u2010based and architecture\u2010reused deep learning methods for generic 3D landmarking of anatomical structures. ShapeMI MICCAI Workshop on Shape in Medical Imaging2024.","DOI":"10.1007\/978-3-031-75291-9_8"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-20887-5_44"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2014.03.005"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11692-009-9055-x"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.2307\/2992207"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1991.tb01825.x"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.23356"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12035"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.2307\/2413249"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/10635150590947258"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-0998.2010.02924.x"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.15413\/ajsr.2018.0502"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115215"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-021-00674-y"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1443-7"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2011.02.023"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2002.00092.x"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470530"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200205000-00002"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38399"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-179936"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2013.03.009"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01897-y"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22709"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12390"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.08.024"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleepadvances\/zpac013"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202403009R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:47:36Z","timestamp":1761677256000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202403009R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":73,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,3,31]]}},"alternative-id":["10.1096\/fj.202403009R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202403009r","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.11.03.24316427","asserted-by":"object"}]},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,24]]},"assertion":[{"value":"2024-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70480"}}