{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:50:02Z","timestamp":1776383402357,"version":"3.51.2"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171852"],"award-info":[{"award-number":["82171852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011933","name":"Chongqing Science and Technology Foundation","doi-asserted-by":"publisher","award":["cstc2021jcyj\u2010msxmX0329"],"award-info":[{"award-number":["cstc2021jcyj\u2010msxmX0329"]}],"id":[{"id":"10.13039\/501100011933","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,4,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Angelman syndrome (AS) is a severe neurodevelopmental disorder with no effective therapies. Most of the behavioral deficits observed in AS patients arise from the absence of ubiquitin protein ligase E3A (UBE3A) in the brain during development, driven by the loss of maternally expressed\n                    <jats:italic>UBE3A<\/jats:italic>\n                    and silencing of the paternal copy of this gene through imprinting. Safe and effective therapies aiming at restoring the expression of the paternal\n                    <jats:italic>UBE3A<\/jats:italic>\n                    gene early in human life are currently lacking. In this study, we investigated whether octanoic acid (OA), a medium\u2010chain fatty acid, could unsilence the paternal\n                    <jats:italic>Ube3a<\/jats:italic>\n                    allele in neurons and ameliorate the behavioral defects in a murine model of AS. To this end,\n                    <jats:italic>Ube3a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>m\u2212\/p+<\/jats:italic>\n                    <\/jats:sup>\n                    and\n                    <jats:italic>Ube3a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>m+\/pYFP<\/jats:italic>\n                    <\/jats:sup>\n                    mice, as well as their wild\u2010type littermates, were fed either a control or OA\u2010supplemented diet from postnatal day 0 through adulthood, and the improvements in AS\u2010related cellular and behavioral deficits were characterized. We demonstrate that dietary intake of OA activates the expression of the silenced, paternal\n                    <jats:italic>Ube3a<\/jats:italic>\n                    in neurons and improves select AS behavioral phenotypes in mice. We further show that downregulation of topoisomerase II beta and restoration of dendritic spine development may underlie the unsilencing of\n                    <jats:italic>Ube3a<\/jats:italic>\n                    and the behavioral improvements in OA\u2010supplemented animals, respectively. Together, our findings suggest that dietary supplementation with OA could serve as an early, safe, and clinically feasible therapeutic strategy for reactivation of the paternal\n                    <jats:italic>UBE3A<\/jats:italic>\n                    allele in patients with AS.\n                  <\/jats:p>","DOI":"10.1096\/fj.202403130rr","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:56:41Z","timestamp":1745567801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dietary Intake of Octanoic Acid Restores\n                    <scp>UBE3A<\/scp>\n                    Expression and Improves the Behavioral Phenotypes in a Mouse Model of Angelman Syndrome"],"prefix":"10.1096","volume":"39","author":[{"given":"Song","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, College of Basic Medical Science Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingying","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, College of Basic Medical Science Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, College of Basic Medical Science Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Undergraduate Student Brigade, College of Basic Medical Science Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pu","family":"Sun","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital of Yongchuan District  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Genetic Metabolism Disease, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5816-7425","authenticated-orcid":false,"given":"Natalia","family":"Surzenko","sequence":"additional","affiliation":[{"name":"Standard Process Inc.  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