{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T02:01:57Z","timestamp":1794276117369,"version":"4.9.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Fatty acid binding protein 7 (FABP7) is prominently expressed in astrocytes and is a critical regulator of inflammatory responses. Accumulating evidence suggests that FABP7 is crucial in neuropsychological disease through the modulation of spinogenesis. Nonetheless, the impact of FABP7 on depressive disorders and the underlying mechanisms is not fully understood. Here, we investigated the antidepressant properties of FABP7 using the chronic unpredictable mild stress (CUMS)\u2010induced model of depression and possible mechanisms. Our results revealed that depressive\u2010like behavior induced by CUMS was associated with decreased levels of FABP7 protein in the hippocampus (HP). Furthermore, the overexpression of FABP7 in the HP mitigated the depressive\u2010like behavior and increased the expression of its downstream target caveolin\u20101 (Cav\u20101). FABP7 overexpression in the HP specifically regulates the expression of the astrocyte marker protein GFAP, as well as the blood\u2013brain barrier (BBB)\u2010associated proteins AQP4, CLDN\u20105, occludin, and LRP1. Notably, the CUMS\u2010induced upregulation of the pro\u2010inflammatory factors IL\u20101\u03b2 and IL\u20106 was also significantly reversed by FABP7 overexpression in the HP. This intervention also led to increased levels of postsynaptic proteins, including PSD95 and GluA1, as well as an increase in brain\u2010derived neurotrophic factor (BDNF) and enhanced neuronal dendritic spine density. The findings indicate that FABP7 exerts antidepressant\u2010like properties by inhibiting inflammation, regulating spinogenesis, and modulating BBB\u2010related proteins.<\/jats:p>","DOI":"10.1096\/fj.202403417rr","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T08:38:37Z","timestamp":1746607117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Astrocytic\n                    <scp>FABP7<\/scp>\n                    Alleviates Depression\u2010Like Behaviors of Chronic Unpredictable Mild Stress Mice by Regulating Neuroinflammation and Hippocampal Spinogenesis"],"prefix":"10.1096","volume":"39","author":[{"given":"Zihui","family":"Geng","sequence":"first","affiliation":[{"name":"Jilin Provinicial Key Laoratory on Molecular and Chemical Genetic Sencond Hospital of Jilin University  Changchun People's Republic of China"},{"name":"Engineering Lab on Screening of Antidepressant Drugs Jilin Province Development and Reform Commission  Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanzhen","family":"Peng","sequence":"additional","affiliation":[{"name":"Jilin Provinicial Key Laoratory on Molecular and Chemical Genetic Sencond Hospital of Jilin University  Changchun People's Republic of China"},{"name":"Engineering Lab on Screening of Antidepressant Drugs Jilin Province Development and Reform Commission  Changchun People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Jilin Provinicial Key Laoratory on Molecular and Chemical Genetic Sencond Hospital of Jilin University  Changchun People's Republic of China"},{"name":"Engineering Lab on Screening of Antidepressant Drugs Jilin Province Development and Reform Commission  Changchun People's Republic of 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