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However, the mechanisms by which\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    induces Treg differentiation, particularly the role of parasite\u2010derived microRNAs (miRNAs), remain largely unexplored. Here, we demonstrate that\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    can significantly induce the differentiation of Treg in mice. Emu\u2010let\u20107\u20105p is upregulated in peripheral blood lymphocyte cells (PBLC) and splenic lymphocytes of\n                    <jats:italic>E. multilocularis\u2010<\/jats:italic>\n                    infected mice. Exosomes enriched with emu\u2010let\u20107\u20105p were found to upregulate the expressions of Treg markers. Conversely, exosomes collected following the knockdown of worm\u2010derived emu\u2010let\u20107\u20105p via RNA interference resulted in a reversal of Treg marker expression in PBLC. Mechanistically, emu\u2010let\u20107\u20105p regulates Treg differentiation by targeting NF\u03baB2. Knockdown of emu\u2010let\u20107\u20105p in\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    \u2010infected mice resulted in diminished Treg differentiation, leading to a significant reduction in worm load. These findings reveal that emu\u2010let\u20107\u20105p drives Treg differentiation by suppressing NF\u03baB2, representing a novel immune evasion strategy of\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    . Sustained inhibition of parasite\u2010derived emu\u2010let\u20107\u20105p may provide a therapeutic avenue for controlling AE progression.\n                  <\/jats:p>","DOI":"10.1096\/fj.202403437r","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T08:47:43Z","timestamp":1746607663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of Host Regulatory T Cell Differentiation by emu\u2010let\u20107\u20105p in\n                    <i>Echinococcus multilocularis<\/i>\n                    Infection Through Targeting\n                    <scp>NF\u03baB2<\/scp>"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2642-1017","authenticated-orcid":false,"given":"Liqun","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Animal Disease Control and Prevention, National Para\u2010Reference Laboratory for Animal 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