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Myeloid\u2010derived suppressor cells (MDSCs) are immune cells with remarkable immunosuppressive functions. We hypothesized that their anti\u2010inflammatory activity may dampen PF by inhibiting inflammation and its transition to fibrosis. Here, we studied the emergence of both polymorphonuclear (PMN)\u2010 and monocytic (M)\u2010MDSCs in a murine model of PF. We assessed immunological, histopathological, and clinical changes at days 3, 7, 14, and 21 following bleomycin challenge. A comprehensive overview of the role of MDSCs during the acute lung injury and chronic phase of pulmonary fibrosis is provided, along with the effects of MDSCs adoptive transfer and depletion. Inflammation and fibrosis increased over a period of 21\u2009days after bleomycin administration. In the lung, the number of PMN\u2010MDSCs increased, while M\u2010MDSCs decreased over the time following bleomycin challenge. Especially, M\u2010MDSCs showed enhanced suppressive activity on day 3 following bleomycin challenge. Adoptive transfer of PMN\u2010MDSCs attenuated inflammation and fibrosis development. However, depletion of PMN\u2010MDSCs did not lead to an exacerbation of PF. Our results suggest that adoptive transfer of PMN\u2010MDSCs can ameliorate the inflammatory responses and thus the development of fibrosis in a bleomycin\u2010induced pulmonary fibrosis model.<\/jats:p>","DOI":"10.1096\/fj.202500312rr","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T03:44:24Z","timestamp":1747107864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterizing the Emergence of Myeloid\u2010Derived Suppressor Cell Subsets in a Murine Model of Pulmonary Fibrosis"],"prefix":"10.1096","volume":"39","author":[{"given":"Nora","family":"Vedder","sequence":"first","affiliation":[{"name":"German Center for Lung Research (DZL) Universities of Giessen and Marburg Lung Center (UGMLC) Philipps University Marburg  Marburg 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