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The mouse model induced by the neurotoxin 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP) is one of the most commonly utilized animal models for PD; however, its ability to accurately replicate the full spectrum of motor and non\u2010motor symptoms remains contentious. In this study, we employed novel MPTP administration regimens (160 and 240\u2009mg\/kg) to examine the behavioral phenotype and pathological alterations induced by MPTP injury, utilizing a combination of behavioral, molecular, and morphological methodologies. Our findings indicate that MPTP\u2010induced subacute PD mice exhibited a significant loss of dopaminergic neurons in the ventral midbrain, accompanied by diffuse astrogliosis and activated microglia. Nonetheless, these mice did not display other prominent movement disorders or mood abnormalities, aside from the gait disturbances associated with the administered MPTP dose. Consequently, we propose that the MPTP\u2010induced subacute PD mouse model utilized in this study represents an early preclinical stage analogous to that observed in human PD patients.<\/jats:p>","DOI":"10.1096\/fj.202500467rr","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:20:10Z","timestamp":1752074410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Two\n                    <scp>MPTP<\/scp>\n                    Doses on Mouse Behaviors and Pathologies"],"prefix":"10.1096","volume":"39","author":[{"given":"Yue","family":"Qi","sequence":"first","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research School of Basic Medicine Sciences, Gannan Medical University  Ganzhou China"},{"name":"Department of Basic Medicine School of Public Health and Health, Xinyu University  Xinyu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research School of Basic Medicine Sciences, Gannan Medical University  Ganzhou China"},{"name":"Department of Laboratory Medicine Jiangxi Hospital of Integrated Chinese and Western Medicine  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Xue","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research School of Basic Medicine Sciences, Gannan Medical University  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhua","family":"Yao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research School of Basic Medicine Sciences, Gannan Medical University  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaying","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research School of Basic Medicine Sciences, Gannan Medical University  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-7653","authenticated-orcid":false,"given":"Xiaolu","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research School of Basic Medicine Sciences, Gannan Medical University  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00330-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557519666191104110908"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-017-8473-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.04.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.04.004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.10.004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136541"},{"key":"e_1_2_11_10_1","first-page":"49","article-title":"MPTP\u2010Induced Parkinsonism in Human and Non\u2010Human Primates\u2014Clinical and Experimental Aspects","volume":"100","author":"Langston J. 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