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This retrospective cohort study seeks to examine the prognosis of AKI progression to CKD post\u2010liver transplantation and to identify its independent risk factors. A cohort of 443 patients who developed AKI post\u2010liver transplantation was analyzed, with participants categorized into a CKD group and a non\u2010CKD group. The progression of AKI to CKD was observed in 29.3% (130 out of 443) of cases. Patients who developed CKD exhibited a significantly higher 1\u2010year mortality rate of 4.6% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Multivariate logistic regression analysis identified several independent risk factors for the progression from AKI to CKD, including preoperative diabetes (odds ratio [OR] 2.62; 95% confidence interval [CI] 1.32, 5.21), hepatic malignancy (OR 1.95; 95% CI 1.06, 3.57), elevated preoperative serum creatinine (SCr) levels (OR 1.02; 95% CI 1.01, 1.03), transition from postoperative AKI to acute kidney disease (AKD) (OR 3.99; 95% CI 1.94, 8.23), AKD stages 2 and 3 (OR 2.48; 95% CI 1.33, 4.61), and an estimated glomerular filtration rate (eGFR) of less than 60\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    within 30\u2009days (OR 3.03; 95% CI 1.70, 5.40). Conversely, higher preoperative hematocrit (HCT) levels (OR 0.00; 95% CI 0.00, 0.26) and recovery from AKD (OR 0.49; 95% CI 0.27, 0.86) were associated with a reduced risk of progression from postoperative AKI to CKD. The progression of AKI to CKD following liver transplantation is independently associated with preoperative diabetes, hepatic malignancy, elevated preoperative SCr levels, postoperative transition from AKI to AKD, AKD stages 2 and 3, and an eGFR of less than 60\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    within 30\u2009days.\n                  <\/jats:p>","DOI":"10.1096\/fj.202500546r","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:39:02Z","timestamp":1756993142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Incidence and Risk Factors for Progression of Acute Kidney Injury to Chronic Kidney Disease After Liver Transplantation: A Retrospective Cohort Study"],"prefix":"10.1096","volume":"39","author":[{"given":"Liping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The Third Affiliated Hospital of SunYat\u2010Sen University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxuan","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Third Affiliated Hospital of SunYat\u2010Sen University  Guangzhou City Guangdong Province China"},{"name":"Department of Anesthesiology Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital  Zhengzhou City Henan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqian","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genomic Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Third Affiliated Hospital of SunYat\u2010Sen University  Guangzhou City Guangdong Province 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