{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:16:32Z","timestamp":1773422192313,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Umbilical cord mesenchymal stem cells (UCMSCs) hold therapeutic potential for acute respiratory distress syndrome (ARDS), but the role of atypical CXC chemokine receptor 7 (CXCR7) in their homing and reparative effects remains unclear. Using a lipopolysaccharide (LPS)\u2010induced ARDS mouse model, we demonstrated that CXCR7 overexpression enhances UCMSC proliferation, migration, and lung repair. Mechanistically, CXCR7 activates the Wnt\/\u03b2\u2010catenin pathway to upregulate murine double minute (MDM2) transcription, which subsequently ubiquitinates and degrades Notch1, revealing a novel Wnt\u2010Notch crosstalk. These findings highlight CXCR7 as a therapeutic target for ARDS and provide insights into UCMSC\u2010based regenerative strategies.<\/jats:p>","DOI":"10.1096\/fj.202500609rr","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:08:39Z","timestamp":1759331319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CXCR7<\/scp>\n                    Facilitates the Migration and Proliferation of\n                    <scp>UCMSCs<\/scp>\n                    via \u03b2\u2010Catenin\/\n                    <scp>TCF4<\/scp>\n                    \/\n                    <scp>MDM2<\/scp>\n                    Signal Regulating Notch1 Ubiquitination to Ameliorate Pulmonary Fibrosis in\n                    <scp>ARDS<\/scp>"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-4243","authenticated-orcid":false,"given":"Yan","family":"Cao","sequence":"first","affiliation":[{"name":"Senior Department of Pulmonary and Critical Care Medicine Chinese PLA Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhirong","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Scientific Research Center The Seventh Affiliated Hospital of Sun Yat Sen University  Shenzhen China"},{"name":"Department of Radiation Oncology Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2651-0258","authenticated-orcid":false,"given":"Yuwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Senior Department of Pulmonary and Critical Care Medicine Chinese PLA Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Jin","sequence":"additional","affiliation":[{"name":"Senior Department of Pulmonary and Critical Care Medicine Chinese PLA Hospital  Beijing China"},{"name":"Chinese PLA Medical School  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Y. B.","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Scientific Research Center The Seventh Affiliated Hospital of Sun Yat Sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xuanwu Hospital, Capital Medical University, Xicheng District  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Xie","sequence":"additional","affiliation":[{"name":"Senior Department of Pulmonary and Critical Care Medicine Chinese PLA Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-3283","authenticated-orcid":false,"given":"Kun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Senior Department of Pulmonary and Critical Care Medicine Chinese PLA Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-076612"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01664-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04287-4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/17534666231158276"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-024-00596-w"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02483-7"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30418-1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM00376K"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15061742"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-62658-7_5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2048984"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020843"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.814947"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noad076"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-10451-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115124"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2016.0331"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.10.002"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11693"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05666-7"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29594"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.04.012"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.068965"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115124"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0253"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.05.003"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26834-3"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.709225"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2004-0330OC"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg6005"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034608"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02402-w"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-196618"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.277038"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611356104"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.108"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.65948"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-05232-5"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110394"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-024-00342-8"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01828-x"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3037"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.2"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI96221"},{"key":"e_1_2_12_46_1","article-title":"The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche","volume":"8","author":"Takam Kamga P.","year":"2020","journal-title":"Frontiers in Cell and Development Biology"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02999-6"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2013.02.001"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10735"},{"issue":"10","key":"e_1_2_12_50_1","first-page":"1464","article-title":"Inhibition of the Notch1\/Jagged1 Pathway Promotes Homing of Bone Mesenchymal Stem Cells to Improve Asthma in Rats","volume":"41","author":"Wang K.","year":"2021","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2512-2"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.08.013"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101558"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950151008"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00688-z"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202500609RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202500609RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202500609RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:32:46Z","timestamp":1773419566000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202500609RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":54,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025,10,15]]}},"alternative-id":["10.1096\/fj.202500609RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202500609rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"2025-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71050"}}