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Despite the notion that resveratrol (RSV) significantly inhibits the growth of PM cancer cells, it is necessary to evaluate the effects of this stilbene as a tumor suppressor agent. In this work, the effects of the natural polyphenol were investigated on PM cell lines (MSTO\u2010211H and IST\u2010MES 2) to evaluate its action as a potential adjuvant agent, together with chemotherapy. Our results showed that RSV treatment was effective in PM cell lines, in particular in MSTO\u2010211H. RES treatment decreases the viability evaluated with the MTT assay and Live\/Dead staining. RSV stimulates the apoptotic process with positive staining for Annexin V\u2010PI and Caspase\u20103\/7 and inhibits the migration ability of both PM cell lines. In IST\u2010MES 2, RSV causes a reduction in mitochondrial and cytoplasmic calcium levels. Moreover, RSV\u00a0affects cellular morphology, E\u2010cadherin protein expression, and decreased nuclear localization of \u03b2\u2010catenin, attenuating Wnt\/\u03b2\u2010catenin signaling, which regulates tumor cell proliferation. At the molecular level, RSV modulated the expression of key genes that play an important role in cellular adhesion, proliferation, and metabolic activity, as well as AMPK signaling. RSV seems to be a promising therapeutic adjuvant agent for PM treatment.<\/jats:p>","DOI":"10.1096\/fj.202500657rr","type":"journal-article","created":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:35:17Z","timestamp":1760888117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Resveratrol Affects Cell Activities, Induces Apoptosis and Regulates\n                    <scp>AMPK<\/scp>\n                    Signaling Pathway in Pleural Mesothelioma Cells"],"prefix":"10.1096","volume":"39","author":[{"given":"Maria Rosa","family":"Iaquinta","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Laboratories of Cell Biology and Molecular Genetics University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"De Pace","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine University of Ferrara  Ferrara 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