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However, the roles of circular RNAs (circRNAs), long non\u2010coding RNAs (lncRNAs), and messenger RNAs (mRNAs) in the early stages of\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    infection, particularly regarding liver involvement, remain unclear. This study aimed to investigate the molecular mechanisms of AE infection in mice during the early stage of secondary infection. The expression profiles of mRNAs, circRNAs and lncRNAs in mouse livers were analyzed at four time points: 2, 4, 8, and 15\u2009days post\u2010infection (dpi). The results identified a substantial number of differentially expressed molecules, including 5004 circRNAs and 8744 lncRNAs. These differentially expressed ncRNAs were mainly involved in immune\u2010related categories, such as antigen processing and presentation and T cell activation. Interactions among circRNAs, lncRNAs, and immune\u2010associated mRNAs formed competing endogenous RNAs (ceRNAs) regulatory networks. Notably, mmu_circ_0008646 showed strong associations with microRNAs such as mmu\u2010miR\u2010466b\u20103p and mmu\u2010miR\u2010574\u20105p, while several lncRNAs also interacted with mmu\u2010miR\u2010574\u20105p. miR\u2010574\u20105p regulates inflammatory responses and macrophage polarization primarily through the NF\u2010\u03baB pathway. Additionally, different components of\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    larva distinctively affect macrophage polarization, with the cystic fluid promoting macrophage M2 polarization and protoscoleces stimulating macrophage M1 polarization. This study highlights alterations in circRNA, lncRNA, and mRNA expression patterns in the livers of mice infected with\n                    <jats:italic>E. multilocularis<\/jats:italic>\n                    , enhancing our understanding of the AE transcriptomic profile.\n                  <\/jats:p>","DOI":"10.1096\/fj.202500662rr","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T11:11:42Z","timestamp":1765624302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcriptomic Profiling of\n                    <scp>mRNAs<\/scp>\n                    ,\n                    <scp>circRNAs<\/scp>\n                    , and\n                    <scp>lncRNAs<\/scp>\n                    in Mouse Liver at the Early Stage of\n                    <i>Echinococcus multilocularis<\/i>\n                    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