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To identify previously unrecognized protein targets in ovarian cancer, we computationally assessed a heptapeptide consensus motif (VPELGHE, flanked by two cysteine residues yielding a cyclic nonapeptide under oxidizing conditions) previously discovered via phage display\u2010based epitope mapping of autoantibodies in patients. Eight proteins associated with ovarian cancer encompass amino acid sequences similar to the consensus motif and were, therefore, considered as candidate native autoantigens. Among these candidate targets, however, matrix metalloproteinase 14 (\n                    <jats:italic>MMP14<\/jats:italic>\n                    ) demonstrates gene expression that is both high and negatively correlated with survival in ovarian cancer patient cohorts. MMP14 protein levels are also stable in tumor versus non\u2010tumor tissues. Moreover, the corresponding heptapeptide mimic in MMP14 occurs within an \u03b1\u2010helical secondary structural element observed in its catalytic domain. These findings demonstrate that a subset of patient\u2010derived autoantibodies may interact with a previously unknown antigenic epitope found in MMP14 and other MMPs, thereby providing opportunities for the development of new targeted agents.\n                  <\/jats:p>","DOI":"10.1096\/fj.202500739rr","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:32:50Z","timestamp":1758630770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Matrix Metalloproteinases as Candidate Antigenic Determinants for Anti\u2010Tumor Autoantibodies in Human Ovarian Cancer: A Post Hoc Analysis"],"prefix":"10.1096","volume":"39","author":[{"given":"Christopher","family":"Markosian","sequence":"first","affiliation":[{"name":"Rutgers Cancer Institute  Newark New Jersey USA"},{"name":"Division of Cancer Biology, Department of Radiation Oncology Rutgers New Jersey Medical School  Newark New Jersey 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