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Recent studies have highlighted the beneficial roles of SCFAs in various physiological and pathological conditions, including diabetes. In this study, we applied streptozotocin (STZ)\u2010induced type 1 diabetes mellitus (T1DM) to investigate the potential role of SCFAs in the pathogenesis of T1DM. We found a significant increase in the abundance of SCFA metabolism\u2010related bacteria in mice surviving after 5 month post\u2010STZ injection (mpi), coupled with improved hyperglycemia. While the expression levels of SCFA receptors, including\n                    <jats:italic>Ffar2<\/jats:italic>\n                    and\n                    <jats:italic>Ffar3<\/jats:italic>\n                    , were significantly upregulated in the intestine of mice at 5\u2009mpi. Consequently, we employed acetate and propionate gavage, which are two of the most dominant SCFAs in the gut and serum, to explore the physiological roles and molecular mechanisms of SCFAs in the progression of T1DM. We found that mice gavaged with acetate had reduced fasting blood glucose levels and less body weight loss. Body composition analysis indicated that acetate administration prevents STZ\u2010induced white adipose tissue (WAT) loss. At the molecular level, acetate treatment increased the genes involved in fatty acid biosynthesis and decreased the protein levels related to lipid catabolism in WAT. In addition, the structure and diversity of gut microbiota were also recovered after acetate treatment in STZ\u2010induced T1D mice. Taken together, our results indicate that acetate is beneficial for T1DM mice by ameliorating STZ\u2010induced hyperglycemia and adipose loss.\n                  <\/jats:p>","DOI":"10.1096\/fj.202500776r","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T10:15:24Z","timestamp":1753352124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acetate Administration Ameliorates Streptozotocin\u2010Induced Hyperglycemia and Adipose Tissue Loss"],"prefix":"10.1096","volume":"39","author":[{"given":"Chi","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Cambridge\u2010Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Cambridge\u2010Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Luo","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Cambridge\u2010Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangpeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Cambridge\u2010Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-2721","authenticated-orcid":false,"given":"Zhihao","family":"Jia","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Cambridge\u2010Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College Soochow University  Suzhou Jiangsu China"},{"name":"Suzhou Municipal Key Lab for Metabolic Syndrome Drug Research, School of Science Xi'an Jiaotong\u2010Liverpool University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Cambridge\u2010Suda Genomic Resource Center, The Fourth Affiliated Hospital, Suzhou Medical College Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/414782a"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaclin.26.2.77"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00510-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.12.2094"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801869"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605223142106"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60591-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.16"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003835"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0827"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1532"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066397"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30014-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10225313"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37420"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2022.06.007"},{"issue":"6382","key":"e_1_2_9_18_1","first-page":"1376","article-title":"Hyperglycemia Drives Intestinal Barrier Dysfunction and Risk for Enteric Infection","volume":"359","author":"Thaiss C. 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