{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T04:25:26Z","timestamp":1761711926977,"version":"build-2065373602"},"reference-count":8,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K08HL155852","R35HL155651"],"award-info":[{"award-number":["K08HL155852","R35HL155651"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,7,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Duchenne Muscular Dystrophy (DMD) is a progressive muscular degenerative disease that is recessively inherited through the X chromosome. Various mutations in the dystrophin gene lead to noticeable muscle weakness. The effects on skeletal and cardiac tissue result in progressive immobility and cardiac dysfunction, respectively. There are several murine models used to study DMD; however, there are still limitations in replicating the pathology of the disease seen in humans with DMD. Myh6cre(Cre) genotypic modification through the Cre\/LoxP system has been proposed to further develop the pathology in murine models to specifically target cardiac tissue while allowing further alteration downstream in the mouse's lifespan. Initial observation of obesity in conjunction with premature death compared to traditional dystrophin\u2010affected mice prompted us to take a further look into fibrosis and cardiac dysfunction. Our findings may help define the phenotype of dystrophin knockout, Cre\u2010positive mice and display the potential for a more accurate, pathological model for DMD.<\/jats:p>","DOI":"10.1096\/fj.202500792r","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T10:04:46Z","timestamp":1752487486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MYH6<\/scp>\n                    \u2010Cre Insertion Accelerates Cardiac Phenotype in Dystrophic\n                    <scp>D2<\/scp>\n                    \u2010\n                    <i>mdx<\/i>\n                    Mice"],"prefix":"10.1096","volume":"39","author":[{"given":"India K.","family":"Hawkins","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Children's Hospital of Richmond at Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trung","family":"Phi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Children's Hospital of Richmond at Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Bioimaging and Applied Research Core Virginia Commonwealth School of Medicine  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Corwin","sequence":"additional","affiliation":[{"name":"Bioimaging and Applied Research Core Virginia Commonwealth School of Medicine  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo G.","family":"Mauro","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Children's Hospital of Richmond at Virginia Commonwealth University  Richmond Virginia USA"},{"name":"Pauley Heart Center, Division of Cardiology, Department of Internal Medicine Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi N.","family":"Salloum","sequence":"additional","affiliation":[{"name":"Pauley Heart Center, Division of Cardiology, Department of Internal Medicine Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Frank J.","family":"Raucci","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Children's Hospital of Richmond at Virginia Commonwealth University  Richmond Virginia USA"},{"name":"Pauley Heart Center, Division of Cardiology, Department of Internal Medicine Virginia Commonwealth University School of Medicine  Richmond Virginia USA"},{"name":"Center for Inherited Muscle Research Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00248-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-210678"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm8040038"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802488R"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24061189"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.03.018"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010362"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2021.11.004"}],"container-title":["The FASEB 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