{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:27:00Z","timestamp":1788805620714,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871173"],"award-info":[{"award-number":["81871173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Preeclampsia (PE) is a severe pregnancy\u2010specific disorder that poses significant risks to maternal and perinatal health. The pathophysiological mechanisms underlying PE are complex and not yet fully elucidated. This study focuses on the role of ferroptosis in PE and identifies a significant downregulation of the transcription factor hepatic leukemia factor (HLF) in PE placental tissues. Further investigations reveal that HLF transcriptionally activates solute carrier family 7 member 11 (SLC7A11) to inhibit trophoblast ferroptosis, thereby maintaining their proliferation, migration, and invasion functions. Additionally, Wilms' tumor 1\u2013associating protein (WTAP), a key factor in N6\u2010methyladenosine (m6A) methylation, regulates HLF mRNA stability in an m6A\u2010dependent manner, influencing the expression of its downstream target SLC7A11. This study, for the first time, systematically clarifies the critical role of the WTAP\/HLF\/SLC7A11 signaling axis in the pathogenesis of PE from the perspective of ferroptosis. The findings offer a novel theoretical basis for further exploration of the molecular mechanisms of PE and potential intervention targets for precision therapy.<\/jats:p>","DOI":"10.1096\/fj.202500937rr","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T12:51:12Z","timestamp":1755607872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>WTAP<\/scp>\n                    Dysregulation Mediates\n                    <scp>HLF<\/scp>\n                    \u2010\n                    <scp>m6A<\/scp>\n                    Modification to Inhibit Trophoblast Ferroptosis in Preeclampsia"],"prefix":"10.1096","volume":"39","author":[{"given":"Shuang","family":"Liu","sequence":"first","affiliation":[{"name":"Shenyang Maternity and Child Health Hospital  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenyang Maternity and Child Health Hospital  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Shenyang Maternity and Child Health Hospital  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Jia","sequence":"additional","affiliation":[{"name":"Shenyang Maternity and Child Health Hospital  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Kang","sequence":"additional","affiliation":[{"name":"Shenyang Maternity and Child Health Hospital  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manni","family":"Sun","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenyang Maternity and Child Health Hospital  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Shenyang Maternity and Child Health Hospital  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7390-3601","authenticated-orcid":false,"given":"Tao","family":"Meng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.014"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12892"},{"key":"e_1_2_12_4_1","article-title":"The Two\u2010Stage Placental Model of Preeclampsia: An Update","volume":"1","author":"Staff A. C.","year":"2019","journal-title":"Journal of Reproductive Immunology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.11.1356"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2298-2"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101402"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102779"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.146"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2018.1536845"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06063-2"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01223-x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00789-5"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06076-5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39401-9"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00450-x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05268-9"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167290"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.04.007"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216144"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noae268"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-022-01225-1"},{"issue":"3","key":"e_1_2_12_23_1","first-page":"1508","article-title":"Hypoxia\u2010Induced Expression of CXCR4 Favors Trophoblast Cell Migration and Invasion via the Activation of HIF\u20101\u03b1","volume":"42","author":"Zhang Z.","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200700RR"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122555"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02443-x"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202500937RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:18:05Z","timestamp":1761675485000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202500937RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":25,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8,31]]}},"alternative-id":["10.1096\/fj.202500937RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202500937rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"2025-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70961"}}