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Using SwissTargetPrediction and GeneCards databases, key overlapping targets, such as CYP19A1, TERT, and PTPN6, were identified, suggesting their involvement as potential therapeutic mediators. Molecular docking simulations confirmed strong binding affinities between 3\u2010epioleanolic acid and these targets. Functional enrichment analysis indicated that the compound may exert therapeutic effects by modulating pathways associated with steroid binding and glucocorticoid metabolism. Transcriptomic data analysis further validated the differential expression of CYP19A1, TERT, and PTPN6 during SONFH progression, underscoring their critical roles in disease development. The CCK\u20108 assay results revealed that 80\u2009\u03bcM 3\u2010epiursolic acid alleviated the proliferation inhibition induced by SONFH. Western blotting and RT\u2010qPCR analyses demonstrated that treatment with 3\u2010epiursolic acid significantly upregulated the expression levels of CYP19A1 and TERT, while markedly downregulating PTPN6 expression. These findings were consistent with the results of bioinformatics analysis, further confirming the regulatory effects of 3\u2010epiursolic acid on these potential targets. Collectively, these findings provide mechanistic insights into the therapeutic potential of 3\u2010epioleanolic acid for SONFH and support its application as a promising candidate for disease intervention and progression monitoring.\n                  <\/jats:p>","DOI":"10.1096\/fj.202500993rrrr","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T09:55:47Z","timestamp":1764323747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Therapeutic Potential of 3\u2010Epioleanolic Acid in Steroid\u2010Induced Osteonecrosis of the Femoral Head Through Network Pharmacology"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-380X","authenticated-orcid":false,"given":"Yimin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Joint Surgery Weifang People's Hospital  Weifang 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