{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:50:34Z","timestamp":1791280234755,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113\u20102311\u2010B\u2010001\u2010018\u2010MY3"],"award-info":[{"award-number":["113\u20102311\u2010B\u2010001\u2010018\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human trophoblast stem (TS) cells differentiate into syncytiotrophoblasts (STBs) through cell\u2013cell fusion, forming the outermost layer of the placental villus to enable nutrient and gas exchange between the mother and fetus. GCM1 (glial cells missing 1) is a placenta\u2010specific transcription factor that regulates STB differentiation by activating the transcription of\n                    <jats:italic>syncytin<\/jats:italic>\n                    and\n                    <jats:italic>hCG\u03b2<\/jats:italic>\n                    genes. Long non\u2010coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides that do not encode proteins. While recent studies suggest that lncRNAs regulate cell differentiation, their role in STB differentiation remains unclear. In this study, we analyzed the transcriptomics of TS cells, as well as TS cell\u2010derived STBs and extravillous trophoblasts, and identified a correlation between the expression of LINC01118 lncRNA and STB\u2010related genes. LINC01118 is highly expressed in first\u2010trimester STBs in the human placenta and is upregulated in BeWo and TS cells upon induction of STB differentiation. Notably, LINC01118 directly interacts with GCM1, enhancing its protein stability and thereby its transcriptional activity, which supports GCM1 autoregulation and the expression of downstream target genes involved in trophoblast fusion and hormone production. In conclusion, we identify LINC01118 as a novel lncRNA that positively regulates GCM1 activity, playing a key role in STB differentiation through its direct interaction with GCM1.\n                  <\/jats:p>","DOI":"10.1096\/fj.202501013rr","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:03:39Z","timestamp":1761066219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Interaction of\n                    <scp>GCM1<\/scp>\n                    and\n                    <scp>LINC01118<\/scp>\n                    Regulates Syncytiotrophoblast Differentiation"],"prefix":"10.1096","volume":"39","author":[{"given":"Liang\u2010Jie","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine Fu Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hsuan","family":"Pao","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Jhen","family":"Tseng","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui\u2010Sze","family":"Ng","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry Academia Sinica  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Shien","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Ming Chuan University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7928-0006","authenticated-orcid":false,"given":"Hungwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry Academia Sinica  Taipei Taiwan"},{"name":"Graduate Institute of Biochemical Sciences National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.11.004"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029312\u20106"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(95)90281\u20103"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(95)90280\u20105"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(Sici)1097\u20100177(199904)214:4<303::Aid\u2010Aja3>3.3.Co;2\u20102"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014\u20105793(98)01650\u20100"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209316200"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.110.083915"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/Mcb.00655\u201015"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/Mcb.00223\u201012"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4835"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/Mcb.25.19.8401\u20108414.2005"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/Mcb.05582\u201011"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700351200"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079598"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13826"},{"key":"e_1_2_12_18_1","first-page":"12718","article-title":"Long 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