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In the present study, we aim to investigate how ADAM9 regulates macrophage efferocytosis during ALI. In the lipopolysaccharide (LPS)\u2010induced ALI mice, inhibiting ADAM9 in macrophages significantly improved ALI, simultaneously reducing the number of macrophages and neutrophils in BALF, along with a decrease in pro\u2010inflammatory cytokines, including IFN\u2010\u03b3, iNOS, and an increase in IL\u20104, IL\u201010. In\u00a0vitro, downregulation of ADAM9 expression in bone marrow\u2010derived macrophages (BMDMs) improved macrophage efferocytosis to apoptotic polymorphonuclear leukocytes (PMNs). Besides, we demonstrated that ADAM9 in BMDMs could directly bind to ITGAV in PMNs; inhibiting ITGAV expression on PMNs effectively improved ADAM9\u2010mediated macrophage efferocytosis. Blocking the interaction between ADAM9 and ITGAV may ameliorate sepsis\u2010induced ALI by promoting macrophage efferocytosis.<\/jats:p>","DOI":"10.1096\/fj.202501079r","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:30:15Z","timestamp":1753875015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Blocking the\n                    <scp>ADAM9<\/scp>\n                    \/\n                    <scp>ITGAV<\/scp>\n                    Pathway Ameliorates Sepsis\u2010Induced Acute Lung Injury by Promoting Macrophage Efferocytosis"],"prefix":"10.1096","volume":"39","author":[{"given":"Long\u2010Zhu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit The First Affiliated Hospital of Jinan University  Guangzhou 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