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Some obese individuals exhibit healthy adipose tissue expansion, characterized by modest inflammation and fibrosis despite adipocyte hypertrophy, resulting in \u201cMetabolically Healthy Obesity (MHO)\u201d. In this study, we investigated the effects of transient weight loss on adipose tissue remodeling during the development of obesity. Male C57BL6\/J mice received various types of transient weight loss treatments during diet\u2010induced obesity. A 2\u2010week weight loss intervention during the inflammatory phase promoted healthy adipose tissue expansion, reduced ectopic lipid accumulation, and improved glucose metabolism. In contrast, protocols with shorter duration and delayed intervention, failed to induce MHO. Since serum concentrations of ketone bodies were elevated during weight loss, we examined the effects of hyperketonemia on obesity\u2010induced adipose tissue remodeling. 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