{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T12:57:48Z","timestamp":1763125068598,"version":"3.45.0"},"reference-count":153,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002830","name":"Centre National d\u2019Etudes Spatiales","doi-asserted-by":"publisher","award":["480000"],"award-info":[{"award-number":["480000"]}],"id":[{"id":"10.13039\/501100002830","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006251","name":"Universit\u00e9 de Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008990","name":"Universit\u00e9 de Lorraine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008222","name":"Universit\u00e9 de Montpellier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008222","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Spaceflight is considered an extreme environment, and from the first days of flight, microgravity causes significant modifications in several physiological systems, particularly the musculoskeletal, cardiovascular, immunological, and nervous systems. To safeguard astronauts' health on upcoming trips, it is crucial to better counteract microgravity's effects using the best prevention methods. With this objective, we launched the NEBULA (Nutrition and Exercise Biology for UnLoaded Astronauts) collaborative research project. The first phase of NEBULA investigates whether a targeted high\u2010intensity pre\u2010flight training program (preconditioning) can delay physiological deconditioning during the initial days of microgravity in a preclinical model. To assess this, sixty 16\u2010week\u2010old male C57BL\/6J mice were split into 6 groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910, each). Half underwent three weeks of preconditioning training (PreC), while the other half remained untrained (Ctrl). Both groups then experienced either 7 or 21\u2009days of hindlimb unloading (HU). Tissue samples\u2014including muscle, bone, tendon, bone marrow, spleen, serum, and brain\u2014were collected at three key time points: post\u2010preconditioning (HU0), after 7\u2009days of HU (HU7), and after 21\u2009days of HU (HU21). At HU0, the PreC group exhibited significantly improved physical performance and enhanced musculoskeletal mass and architecture compared to Ctrl. In the Ctrl group, HU induced severe bone and muscle deconditioning by HU7, which was worsened by HU21. However, in the PreC group, the initial improvements in bone and muscle structure were maintained through HU7 before declining by HU21. Importantly, the high intensity and frequency of training did not negatively impact tendon integrity or immune function and appeared to prevent the decline in adult neurogenesis typically associated with both intense exercise and microgravity. These findings highlight the broad systemic benefits of pre\u2010flight physical conditioning in delaying the adverse effects of reduced mechanical load, such as those experienced during spaceflight or prolonged bed rest. Additionally, they underscore the potential for preconditioning to support more effective countermeasures when physical exercise is unavailable for extended periods.\n                  <\/jats:p>","DOI":"10.1096\/fj.202501128r","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T11:26:16Z","timestamp":1751628376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resistance and Aerobic Preconditioning Delays Unloading\u2010Induced Multisystemic Physiological Changes: The\n                    <scp>NEBULA<\/scp>\n                    Project"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9712-4672","authenticated-orcid":false,"given":"Th\u00e9o","family":"Fovet","sequence":"first","affiliation":[{"name":"SAINBIOSE\u2010U1059, INSERM Universit\u00e9 Jean Monnet, Mines Saint\u2010Etienne  Saint\u2010Etienne France"},{"name":"Centre National d'\u00c9tudes Spatiales (CNES)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Issertine","sequence":"additional","affiliation":[{"name":"DMEM Universit\u00e9 de Montpellier, INRAE  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Jacob","sequence":"additional","affiliation":[{"name":"Stress, Immunity, Pathogens Laboratory, SIMPA Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Ghislin","sequence":"additional","affiliation":[{"name":"Stress, Immunity, Pathogens Laboratory, SIMPA Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Laroche","sequence":"additional","affiliation":[{"name":"SAINBIOSE\u2010U1059, INSERM Universit\u00e9 Jean Monnet, Mines Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Roffino","sequence":"additional","affiliation":[{"name":"CNRS, ISM, Institute of Movement Sciences Aix Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3691-8193","authenticated-orcid":false,"given":"Claire","family":"Camy","sequence":"additional","affiliation":[{"name":"CNRS, ISM, Institute of Movement Sciences Aix Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Theuil","sequence":"additional","affiliation":[{"name":"DMEM Universit\u00e9 de Montpellier, INRAE  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Bertrand\u2010Gaday","sequence":"additional","affiliation":[{"name":"DMEM Universit\u00e9 de Montpellier, INRAE  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Delobel","sequence":"additional","affiliation":[{"name":"DMEM Universit\u00e9 de Montpellier, INRAE  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Chabi","sequence":"additional","affiliation":[{"name":"DMEM Universit\u00e9 de Montpellier, INRAE  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Ollendorff","sequence":"additional","affiliation":[{"name":"DMEM Universit\u00e9 de Montpellier, INRAE  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Py","sequence":"additional","affiliation":[{"name":"DMEM Universit\u00e9 de Montpellier, INRAE  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-6269","authenticated-orcid":false,"given":"Jean\u2010Pol","family":"Frippiat","sequence":"additional","affiliation":[{"name":"Stress, Immunity, Pathogens Laboratory, SIMPA Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8079-6851","authenticated-orcid":false,"given":"Jean\u2010Luc","family":"Morel","sequence":"additional","affiliation":[{"name":"CNRS, INCIA, UMR 5287 Univ. Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Vico","sequence":"additional","affiliation":[{"name":"SAINBIOSE\u2010U1059, INSERM Universit\u00e9 Jean Monnet, Mines Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Brioche","sequence":"additional","affiliation":[{"name":"DMEM Universit\u00e9 de Montpellier, INRAE  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Strigini","sequence":"additional","affiliation":[{"name":"SAINBIOSE\u2010U1059, INSERM Universit\u00e9 Jean Monnet, Mines Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e8le","family":"Chopard","sequence":"additional","affiliation":[{"name":"DMEM Universit\u00e9 de Montpellier, INRAE  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010017\u20100013\u20100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950181215"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297923110081"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjmgrav.2016.13"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010023\u201000258\u20103"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.37"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201013461\u20101"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010021\u201000158\u20104"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010022\u201000194\u20108"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(00)02217\u20100"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3188"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582\u20104934.2009.00864.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768\u2010200010000\u201000013"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.5.1733"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.188508"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000001191"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01083.2005"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01266.2004"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200713R"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2023.101211"},{"key":"e_1_2_11_22_1","first-page":"421","article-title":"The Effects of Space Microgravity on Hip and Knee Cartilage: A New Frontier in Orthopaedics","volume":"35","author":"Ramkumar P. N.","year":"2019","journal-title":"Surgical Technology International"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010023\u201000253\u20108"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S114188"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010023\u201000294\u2010z"},{"issue":"4","key":"e_1_2_11_26_1","first-page":"383","article-title":"Hematology and Immunology Studies: The Second Manned Skylab Mission","volume":"47","author":"Kimzey S. L.","year":"1976","journal-title":"Aviation, Space, and Environmental Medicine"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010024\u201000446\u20109"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201090458\u20102"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.07.045"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00968.2002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979\u2010023\u201000393\u20101"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092664"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12\u2010217547"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801463R"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210000330"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26638"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2014"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.104596"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1051\/jbio\/2015028"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13728\u2010016\u20100050\u20104"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273895"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222112064"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182970"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010148"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.834597"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3765643"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057141"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12970\u2010020\u201000390\u20105"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.05.002"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12809"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00997.2015"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2013.05.027"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12259"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076\u20106879(67)10048\u20107"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076\u20106879(69)13005\u20100"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102818.1997.1340694.x"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.3.561"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116640"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.04.021"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2016.10.022"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029769"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16244897"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201088105\u2010x"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1139\/h04\u2010002"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13725"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/19417381211044739"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256\u2010199826010\u201000001"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101312627"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002929"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00895.2004"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.034850"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.2.E265"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/sports9090127"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201027153\u20103"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.10.012"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.40.3.379"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256\u2010200232010\u201000003"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00636.2019"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00969.2001"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10\u2010177295"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.276.2.R308"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107580.2008.00854.x"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00284"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.2.823"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00071"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010015\u20109848\u2010z"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.275545"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20101716.2009.01984.x"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25737"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00063"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913935107"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00289.2017"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.28.2072"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00137.2018"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.02.021"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00663.2013"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210000195"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555089"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650101118"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.06.008"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/life10100217"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102004\u2010820942"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914\u2010023\u201000825\u20103"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010017\u20101498\u20108"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2018.33.4.435"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198466030-00012"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.10119"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.5.918"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109290(82)90092\u20106"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553711"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.4.656"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00298721"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201049432\u20102"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002230010001"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102021\u2010104634"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657\u2010017\u20100324\u20105"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010021\u201000147\u20107"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.9.1596"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10020342"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010020\u20100103\u20102"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.10.008"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo\u2010118\u20102\u2010733"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4029176"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.25233"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2024.112231"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102015\u2010095422"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12030456"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.4.580"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119773"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lssr.2021.03.001"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14\u2010259770"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01147"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2024.2320780"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2020.104741"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889\u20101591(90)90013\u2010g"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077935"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306\u20104530(02)00039\u20102"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010014\u20101203\u20100"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.08.007"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003298\u20105"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.12.016"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201012\u2010323113"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.10.016"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010024\u201000411\u20106"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00013"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2016.02.001"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104676"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221\u2010008\u20101523\u20105"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427\u2010021\u20101932\u20103"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111759"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010022\u201000217\u20104"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15407"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526\u2010024\u201000441\u20100"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202501128R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T12:54:03Z","timestamp":1763124843000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202501128R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":153,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,7,15]]}},"alternative-id":["10.1096\/fj.202501128R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202501128r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"type":"print","value":"0892-6638"},{"type":"electronic","value":"1530-6860"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"2025-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70759"}}