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It plays a pivotal role in craniofacial biology by maintaining bone homeostasis, facilitating dentin mineralization, periodontal remodeling, and orthodontic tooth movement. Expressed in bone tissue, dental pulp stem cells, and periodontal ligament cells, dysregulated PIEZO1 is implicated in a number of conditions, including osteoporosis, dentin hypersensitivity, temporomandibular disorders, and periodontitis. The therapeutic potential of chemical modulators such as Yoda1 (an agonist) and GsMTx4 (an inhibitor) has been demonstrated; however, their clinical translation remains limited. Future research should focus on elucidating molecular mechanisms, signaling cascades, and species differences to advance PIEZO1\u2010targeted therapies, offering novel strategies for managing craniofacial disorders and enhancing regenerative approaches in dentistry.\n                  <\/jats:p>","DOI":"10.1096\/fj.202501130r","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T13:49:18Z","timestamp":1755870558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>PIEZO1<\/scp>\n                    \u2010Mediated Mechanotransduction in Craniofacial Biology"],"prefix":"10.1096","volume":"39","author":[{"given":"Yutong","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School and Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School and Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendong","family":"Tao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School and Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Hua","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral and Maxillofacial Reconstruction and 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