{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:09:53Z","timestamp":1787155793220,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202401073ZYTS"],"award-info":[{"award-number":["YDZJ202401073ZYTS"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202201ZYTS276"],"award-info":[{"award-number":["YDZJ202201ZYTS276"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pediatric bacterial pneumonia continues to pose a significant global health burden, often resulting in serious complications. Recent studies have emphasized the pivotal role of the gut\u2010lung axis in the progression of respiratory diseases, wherein disruptions in gut microbiota can aggravate pulmonary inflammation. This research investigates the underlying mechanisms by which Ma\u2010Xing\u2010Shi\u2010Gan Decoction (MXSG), a classical formula in traditional Chinese medicine, influences the gut\u2010lung axis in the context of childhood bacterial pneumonia. Clinical data indicated pronounced alterations in intestinal microbial composition and a marked decline in short\u2010chain fatty acid (SCFA) levels among affected pediatric patients\u2014changes that coincided with dysfunctional gut\u2010lung signaling. In a murine model of bacterial pneumonia, MXSG administration restored microbial diversity, elevated SCFA production, and attenuated inflammatory responses by suppressing the HDAC3\/NF\u2010\u03baB signaling cascade. Key bioactive constituents of MXSG\u2014namely, quercetin, osajin, nobiletin, and solasodine\u2014were identified as critical regulators, modulating lipid metabolism and promoting SCFA biosynthesis. These results highlight the therapeutic promise of MXSG in reestablishing gut\u2010lung homeostasis and shed light on its mechanistic potential in the treatment of pediatric bacterial pneumonia.<\/jats:p>","DOI":"10.1096\/fj.202501200r","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T11:37:01Z","timestamp":1755257821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ma\u2010Xing\u2010Shi\u2010Gan Decoction Modulates the Gut\u2010Lung Axis in Pediatric Bacterial Pneumonia via\n                    <scp>HDAC3<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Signaling and\n                    <scp>SCFA<\/scp>\n                    Restoration"],"prefix":"10.1096","volume":"39","author":[{"given":"Lina","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital to Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital to Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Affiliated Hospital to Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital to Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital to Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital to Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongji","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital to Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Affiliated Hospital to Changchun University of Chinese Medicine  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010021\u201000426\u20104"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13915"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.5547"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00459"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010021\u201001063\u20105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010021\u201000649\u2010x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1419685"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12908"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x21500373"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.581691"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.ijmr_1678_19"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010321031"},{"key":"e_1_2_10_14_1","volume-title":"StatPearls","author":"Sattar S. 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