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This is mainly because the disease has low immunogenicity, and its complex immune microenvironment limits the efficacy of single immunotherapy. Researchers are increasingly exploring novel immunotherapy strategies for this disease. Key approaches include immune checkpoint inhibitors (ICIs), which restore T cell function and enhance cytotoxic T lymphocyte (CTL) activity; cell therapies that target tumor\u2010associated antigens; cancer vaccines that stimulate immune responses against prostate cancer; and bispecific antibodies (BsAbs) that link tumor cells and T cells to promote tumor eradication. Combination therapies integrating immunotherapy with conventional treatments such as chemotherapy, androgen deprivation therapy (ADT), and radiotherapy further show potential to overcome prostate cancer's immunosuppressive microenvironment. 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