{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:00:43Z","timestamp":1784070043851,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017054","name":"National Natural Science Foundation of China-Zhejiang Joint Fund for the Integration of Industrialization and Informatization","doi-asserted-by":"publisher","award":["82204837"],"award-info":[{"award-number":["82204837"]}],"id":[{"id":"10.13039\/100017054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017054","name":"National Natural Science Foundation of China-Zhejiang Joint Fund for the Integration of Industrialization and Informatization","doi-asserted-by":"publisher","award":["81760207"],"award-info":[{"award-number":["81760207"]}],"id":[{"id":"10.13039\/100017054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To investigate the effect of dipeptidyl peptidase 4 (DPP4) on cognitive impairment in Alzheimer's disease (AD), the present study used seven\u2010week\u2010old male C57BL\/6J and DPP4 knockout mice. The AD model was induced by microinjection of A\u03b2\n                    <jats:sub>25\u201035<\/jats:sub>\n                    into the lateral ventricle. Morris water maze test showed that DPP4 knockout significantly improved the spatial learning and memory abilities of AD mice. Western blot results showed that DPP4 knockout increased the expression levels of BDNF, CREB and Bcl\u20102 in the hippocampus of AD mice while the expression levels of Caspase\u20108, pyroptosis\u2010related proteins NLRP3, Caspase\u20101, GSDMD, IL\u2010118, IL\u20101\u03b2, and apoptosis\u2010related proteins Caspase\u20103 and Bax were decreased. Similar results were observed after HT22 neurons were treated with A\u03b2\n                    <jats:sub>25\u201035<\/jats:sub>\n                    and the DPP4 inhibitor sitagliptin (Sit). Moreover, the treatment with a Caspase\u20108 inhibitor (Z\u2010LETD\u2010FMK) showed that the inhibition of Caspase\u20108 inhibited the expression of NLRP3 and Caspase\u20101 in the AD model cells, but had no further inhibitory effect under the treatment of Sit. Our results suggest that DPP4 knockout may ameliorate learning and memory dysfunction in AD model mice by regulating pyroptosis and apoptosis pathways through Caspase\u20108.\n                  <\/jats:p>","DOI":"10.1096\/fj.202501322rr","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:36:06Z","timestamp":1764254166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dipeptidyl Peptidase 4 Mediated Caspase\u20108 Affects Cognitive Impairment in Mice With Alzheimer's Disease"],"prefix":"10.1096","volume":"39","author":[{"given":"XinYi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology Jiaxing University Medical College  Jiaxing China"},{"name":"State Key Laboratory of Brain Function and Disorders Institutes of Brain Science, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Northeast Yunnan Regional Central Hospital  Zhaotong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaYao","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Jiaxing University Medical College  Jiaxing China"},{"name":"College of Life Sciences and Medicine, Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Jiaxing University Medical College  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PeiYan","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Jiaxing University Medical College  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XianWu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Hypertension Yanbian University Hospital  Yanji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Jiaxing University Medical College  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiYing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Jiaxing University Medical College  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/713609354"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201050507\u20103"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00247"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114578"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00108"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101770\u20106"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.157433"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3333"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7222590"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.01.030"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.09.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.669202"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11121885"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/368703"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13373"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317519899546"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3509"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2021.107463"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302839"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.872471"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15439"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.830863"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2014.09.010"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010019\u201003101\u20102"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2018.06.006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8289"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202501322RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202501322RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202501322RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:24:15Z","timestamp":1772987055000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202501322RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":26,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2025,12,15]]}},"alternative-id":["10.1096\/fj.202501322RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202501322rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]},"assertion":[{"value":"2025-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71264"}}