{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:49:42Z","timestamp":1793980182309,"version":"4.8.0"},"reference-count":40,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203471"],"award-info":[{"award-number":["82203471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    C\/EBP\u03b2, a member of the CCAAT\/enhancer\u2010binding protein (C\/EBP) family of transcription factors, is implicated in monocyte differentiation, inflammation, and cancer progression. However, the distinct roles of its transcriptional activator (LAP) and repressor (LIP) isoforms in triple\u2010negative breast cancer (TNBC) pathogenesis remain unclear. In this study, we demonstrate that LAP critically promotes TNBC growth, whereas single\u2010cell RNA sequencing reveals that LAP overexpression drives CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell exhaustion, whereas LIP primarily modulates CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell function. Integrative ATAC\u2010seq, ChIP\u2010seq, and RNA\u2010seq analyses further show that LAP enhances chromatin accessibility and activates the EGFR signaling pathway, whereas LIP exerts minimal effects on TNBC phenotypes. These findings establish LAP as a key oncogenic driver in TNBC and unveil its immunosuppressive role in shaping the tumor microenvironment, offering potential therapeutic targets for TNBC treatment.\n                  <\/jats:p>","DOI":"10.1096\/fj.202501330r","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T12:45:46Z","timestamp":1756125946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Divergent Roles of C\/\n                    <scp>EBP\u03b2<\/scp>\n                    Isoforms\n                    <scp>LAP<\/scp>\n                    and\n                    <scp>LIP<\/scp>\n                    in Shaping T Cell Dysfunction and Tumor Progression in Triple\u2010Negative Breast Cancer"],"prefix":"10.1096","volume":"39","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medicine Sciences Hangzhou Normal University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medicine Sciences Hangzhou Normal University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Shen","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medicine Sciences Hangzhou Normal University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medicine Sciences Hangzhou Normal University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Gao","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medicine Sciences Hangzhou Normal University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medicine Sciences Hangzhou Normal University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abj0140"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2023.11.011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.115039"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.02.007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2012.11.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20333"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26579-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22985"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14011"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2426-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0701-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34962"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1447-7"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-00815-4"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.13138"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-021-00372-z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.04.022"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.107"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-3-r16"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01767-y"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2859"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.02.070"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.11.6609"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115938"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01943-07"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2021.1840984"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1102778"},{"issue":"12","key":"e_1_2_11_35_1","first-page":"4585","article-title":"T Lymphocytes in Hepatocellular Carcinoma Immune Microenvironment: Insights Into Human Immunology and Immunotherapy","volume":"10","author":"Bian J.","year":"2020","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0175-7"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137346"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01234-1"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.06.014"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1263537"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.70958"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202501330R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:18:20Z","timestamp":1761675500000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202501330R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":40,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8,31]]}},"alternative-id":["10.1096\/fj.202501330R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202501330r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,25]]},"assertion":[{"value":"2025-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70984"}}