{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:39:29Z","timestamp":1761676769264,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR078695","R01DK132819","R01AR079235"],"award-info":[{"award-number":["R01AR078695","R01DK132819","R01AR079235"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The pancreas regulates metabolic homeostasis through exocrine and endocrine pathways. Dysfunction or loss of pancreatic \u03b2\u2010cells causes diabetes. Here we explore the role of Polo\u2010like kinase 1 (PLK1) in the pancreas using a pancreatic\u2010lineage specific knockout (\n                    <jats:italic>Plk1<\/jats:italic>\n                    <jats:sup>PKO<\/jats:sup>\n                    ) mouse model.\n                    <jats:italic>Plk1<\/jats:italic>\n                    <jats:sup>PKO<\/jats:sup>\n                    leads to partial pancreatic agenesis, diminishing pancreatic mass. Adult\n                    <jats:italic>Plk1<\/jats:italic>\n                    <jats:sup>PKO<\/jats:sup>\n                    mice exhibit diabetic syndromes including hyperglycemia, glucose intolerance, and insulin hypersensitivity.\n                    <jats:italic>Plk1<\/jats:italic>\n                    <jats:sup>PKO<\/jats:sup>\n                    mice also exhibit growth retardation and reduced skeletal muscle and adipose tissue masses. Furthermore,\n                    <jats:italic>Plk1<\/jats:italic>\n                    <jats:sup>PKO<\/jats:sup>\n                    mice develop metabolic adaptation towards fatty acid utilization, manifested by elevated oxygen consumption (VO\n                    <jats:sub>2<\/jats:sub>\n                    ), reduced respiratory exchange ratio (RER), and more oxidative myofibers. These findings reveal a key role of PLK1 in pancreas development.\n                  <\/jats:p>","DOI":"10.1096\/fj.202501377r","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:25:48Z","timestamp":1755084348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Mouse Model of Partial Pancreas Agenesis Induced by\n                    <i>Polo\u2010like kinase 1<\/i>\n                    Mutation"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0598-6189","authenticated-orcid":false,"given":"Xiyue","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Animal Sciences Purdue University  West Lafayette Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-2721","authenticated-orcid":false,"given":"Zhihao","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Purdue University  West Lafayette Indiana USA"},{"name":"Cambridge\u2010Suda Genomic Resource Center, Suzhou Medical College Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-3180","authenticated-orcid":false,"given":"Shihuan","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Purdue University  West Lafayette Indiana USA"},{"name":"Department of Orthopedic Surgery and Department of Pathology Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke Cancer Institute  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.904004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01245-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2018.04.011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47097"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00392-08"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.02.004"},{"key":"e_1_2_9_9_1","first-page":"59","article-title":"Genetic Depletion of Polo\u2010Like Kinase 1 Leads to Embryonic Lethality due to Mitotic Aberrancies","volume":"1","author":"Wachowicz P.","year":"2016","journal-title":"Cell"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63352"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1799-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.6.2498-2510.2005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308617100"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0590"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1887-P"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-022-10088-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0370-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0016"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202501377R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:17:24Z","timestamp":1761675444000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202501377R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":17,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8,31]]}},"alternative-id":["10.1096\/fj.202501377R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202501377r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"type":"print","value":"0892-6638"},{"type":"electronic","value":"1530-6860"}],"subject":[],"published":{"date-parts":[[2025,8,13]]},"assertion":[{"value":"2025-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70946"}}