{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:29:49Z","timestamp":1791862189040,"version":"4.3.4"},"reference-count":275,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Condensate\u2010modifying therapeutics (c\u2010mods), comprising low\u2013molecular\u2010weight compounds (~1.5\u2009kDa) and related agents such as RNAs and metabolites like ATP, are emerging as promising drug candidates for neurodegenerative disorders, cancer, and viral infections. These compounds modulate liquid\u2013liquid phase separation (LLPS), a biophysical process driven by intrinsically disordered regions, low\u2010complexity domains, and multivalent non\u2010covalent interactions (hydrogen bonds, van der Waals forces, hydrophobic, and electrostatic interactions). LLPS governs the formation of biomolecular condensates essential for gene regulation, signaling, stress responses, and cellular organization. By selectively inhibiting or promoting condensation, we show that c\u2010mods offer strategies to manage diseases presented with aberrant phase separation. Mechanistic insights into LLPS dynamics provided by specific physicochemical features (planar structures and polarity) of c\u2010mods open avenues for accelerating drug discovery, repurposing, and synergistic therapies. We highlight scaffolds, charged molecules, and ions that modulate LLPS. We integrate recent advances in understanding the roles of c\u2010mods in regulating viral protein assemblies; however, the function of LLPS and its regulation in other microorganisms remains underexplored. Future directions include engineering peptide\u2010based therapeutics, designing artificial condensates, and employing AI\u2010driven target identification to discover novel LLPS\u2010associated drug targets. Additionally, biomaterials and industry\u2010led initiatives in condensate\u2010targeted drug discovery are broadening therapeutic intervention across diverse diseases.<\/jats:p>","DOI":"10.1096\/fj.202501476r","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T05:55:33Z","timestamp":1751694933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Small Molecules as Regulators of Liquid\u2013Liquid Phase Separation: Mechanisms and Strategies for New Drug Discovery"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5477-6976","authenticated-orcid":false,"given":"Abdurrahman","family":"Usman","sequence":"first","affiliation":[{"name":"Chinese\u2010German Joint Institute for Natural Product Research, Shaanxi International Cooperation Demonstration Base for Science and Technology Shaanxi University of Technology  Hanzhong Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2811-089X","authenticated-orcid":false,"given":"Anas","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Chinese\u2010German Joint Institute for Natural Product Research, Shaanxi International Cooperation Demonstration Base for Science and Technology Shaanxi University of Technology  Hanzhong Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8883-3354","authenticated-orcid":false,"given":"Murtala Bindawa","family":"Isah","sequence":"additional","affiliation":[{"name":"Chinese\u2010German Joint Institute for Natural Product Research, Shaanxi International Cooperation Demonstration Base for Science and Technology Shaanxi University of Technology  Hanzhong Shaanxi China"},{"name":"Department of Biochemistry Umaru Musa Yar'adua University  Katsina Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2660-3323","authenticated-orcid":false,"given":"Mei","family":"Dang","sequence":"additional","affiliation":[{"name":"Chinese\u2010German Joint Institute for Natural Product Research, Shaanxi International Cooperation Demonstration Base for Science and Technology Shaanxi University of Technology  Hanzhong Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-7322","authenticated-orcid":false,"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese\u2010German Joint Institute for Natural Product Research, Shaanxi International Cooperation Demonstration Base for Science and Technology Shaanxi University of Technology  Hanzhong Shaanxi China"},{"name":"Centre of Molecular and Environmental Biology (CBMA), department of Biology University of Minho, Campus de Gualtar  Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53494-w"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022112863"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.331520.119"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00678-1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0550-8"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03703-z"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.002"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25806"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000327"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00025"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00006-X"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1656-20.2020"},{"key":"e_1_2_13_14_1","first-page":"3766","article-title":"Liquid\u2013Liquid Phase Separation (LLPS) in Cellular Physiology and Tumor Biology","volume":"11","author":"Peng P.\u2010H.","year":"2021","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102435"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006620"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00655-9"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3958"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015418"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36189-6"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15007-3"},{"key":"e_1_2_13_22_1","doi-asserted-by":"crossref","unstructured":"A.MahapatraandR. W.Newberry Liquid\u2013Liquid Phase Separation of \u03b1\u2010Synuclein is Highly Sensitive to Sequence Complexity(2023).","DOI":"10.1101\/2023.08.03.551831"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.037"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2020.11.003"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2024.02.007"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2020.09.004"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR05130G"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.962526"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c09557"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-024-01489-x"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2024.168607"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS01065A"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-55582-9"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SM00358F"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04767-5"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-022-00075-2"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01380-1"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01518-9"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798049"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.047"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19211-z"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-823967-4.00005-1"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1np00051a"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR08338D"},{"key":"e_1_2_13_45_1","unstructured":"P. R.Haag A New Approach to Antiviral Drugs(2012)."},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00505-4"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16959"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00237"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.001"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-019-0193-2"},{"key":"e_1_2_13_51_1","unstructured":"I.Takashi S.Takeshi S.Yasushi andK.Hiroshi RNA Polymerase II Condensate Formation and Association With Cajal and Histone Locus Bodies in Living Human Cells(2020)."},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18413"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614462114"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202302101"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02455-3"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100260"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02456-2"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12238"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12578"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205015666180411092551"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2019.129467"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0141-z"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39151-8"},{"key":"e_1_2_13_64_1","unstructured":"R. J.Wheeler H. O.Lee I.Poser et\u00a0al. Small Molecules for Modulating Protein Driven Liquid\u2013Liquid Phase Separation in Treating Neurodegenerative Disease(2019)."},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.05.048"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14229"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00504-x"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22386"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.01.032"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008056"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000504"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physchem-040412-110156"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC07151C"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011157"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.093"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201707850"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.3465"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a003261"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1468-6996(03)00007-X"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn300170x"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29846-9"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08004"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.03.046"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13180"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.4161\/rdis.26657"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja050918w"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.11.041"},{"key":"e_1_2_13_88_1","doi-asserted-by":"crossref","unstructured":"A.Jack L. S.Ferro M. J.Trnka et\u00a0al. \u201cSARS\u2010CoV\u20102 Nucleocapsid Protein Forms Condensates With Viral Genomic RNA \u201dPlos Biol19 (2021): e3001425.","DOI":"10.1371\/journal.pbio.3001425"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1768151"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-021-00832-z"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22297-8"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.017"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.027"},{"key":"e_1_2_13_94_1","doi-asserted-by":"crossref","unstructured":"H. B.Schmidt Z. A.Jaafar J. J.Rodencal et\u00a0al. \u201cOxaliplatin Kills Cells via Liquid\u2013Liquid Demixing of Nucleoli \u201d (2021).bioRxiv2021.06.10.447918.","DOI":"10.1101\/2021.06.10.447918"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.01.010"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101517"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.04.001"},{"key":"e_1_2_13_98_1","article-title":"Pharmacological Inhibition of Core Regulatory Circuitry Liquid\u2013liquid Phase Separation Suppresses Metastasis and Chemoresistance in Osteosarcoma","volume":"8","author":"Lu B.","year":"2021","journal-title":"Advancement of Science"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01151-y"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.121709"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8920060"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89075-w"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.716919"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10879"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2401834121"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22989"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.336487.120"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.01.009"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19435-z"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20220314"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00575-7"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20768-y"},{"key":"e_1_2_13_113_1","article-title":"Molecular Insights Into the Effect of Alkanediols on FUS Liquid\u2013Liquid Phase Separation","author":"Perdikari T. M.","year":"2022","journal-title":"Biophysical Journal"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41864-9"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036122"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.2.534-542.2003"},{"key":"e_1_2_13_117_1","first-page":"277","article-title":"Alcohol, Oxidative Stress, and Free Radical Damage","volume":"27","author":"Wu D.","year":"2003","journal-title":"Alcohol Research & Health"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14546-z"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/minf.202300339"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009328"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202112024"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.2142\/biophysico.BSJ-2019052"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26010106"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000663"},{"key":"e_1_2_13_125_1","unstructured":"J.ChoiandR.Pappu Stickers and Spacers Framework for Phase Transitions of Multivalent Intrinsically Disordered Proteins(2018)."},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b03570"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70600-4"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.11.008"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06564.x"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.007222"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020209"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.201700762"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74271-x"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2414"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2020.11.429"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43246-024-00597-y"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.03.040"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115189"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2018.09.006"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00614"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06396"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2921"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-3-15"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-32361-6"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c03534"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.609756"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1177\/11779322241240651"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39490"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki809"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2009.03.009"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2020.105782"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106449"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150927"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab008"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00008.2015"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm034093h"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161274798"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1545"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000115115.98960.37"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.667859"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.13.7185"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20010185"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16091739"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102271"},{"key":"e_1_2_13_166_1","doi-asserted-by":"crossref","unstructured":"T. M.Perdikari A. C.Murthy V. H.Ryan S.Watters M. T.Naik andN. L.Fawzi \u201cSARS\u2010CoV\u20102 Nucleocapsid Protein Undergoes Liquid\u2013Liquid Phase Separation Stimulated by RNA and Partitions Into Phases of Human Ribonucleoproteins \u201d (2020). 2020.06.09.141101.","DOI":"10.1101\/2020.06.09.141101"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19843-1"},{"key":"e_1_2_13_168_1","doi-asserted-by":"crossref","unstructured":"Y.Ge T.Tian S.Huang et\u00a0al. \u201cA Data\u2010Driven Drug Repositioning Framework Discovered a Potential Therapeutic Agent Targeting COVID\u201019 \u201d (2020). 2020.03.11.986836.","DOI":"10.1101\/2020.03.11.986836"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00819"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02308-8"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0149"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.11.004"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1397"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18621"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2014-102611"},{"key":"e_1_2_13_176_1","article-title":"Phase Separation of SHP2E76K Promotes Malignant Transformation of Mesenchymal Stem Cells by Activating Mitochondrial Complexes","volume":"9","author":"Kan C.","year":"2024","journal-title":"JCI Insight"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2409.06116"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42144"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.8266"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3630"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0817"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00214-012-1092-3"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011604"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2017.08.033"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cinorg.2024.100041"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139960"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101469"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193145"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.AC120.013166"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102857"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/971021"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.036"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.960806"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12101179"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.AC119.009198"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15756"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.08.037"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2006.09.007"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.112.003038"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115679"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.02.003"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC04907D"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21181-9"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1295\/polymj.37.234"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab063"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4108"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2022.108287"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2016.06.006"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01292"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2006.01.015"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CP00847E"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00463"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10118-022-2763-8"},{"key":"e_1_2_13_214_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-0557-7_2"},{"key":"e_1_2_13_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2023.168263"},{"key":"e_1_2_13_216_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27285-6"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.10.010"},{"key":"e_1_2_13_218_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06811-4"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00147-X"},{"key":"e_1_2_13_220_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25132-1"},{"key":"e_1_2_13_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.030"},{"key":"e_1_2_13_222_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06072-w"},{"key":"e_1_2_13_223_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c01372"},{"key":"e_1_2_13_224_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2002183"},{"key":"e_1_2_13_225_1","first-page":"564","article-title":"Aberrant Phase Separation and Nucleolar Dysfunction in Rare Genetic Diseases","volume":"614","author":"Mensah M.","year":"2023","journal-title":"Nature"},{"key":"e_1_2_13_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.047"},{"key":"e_1_2_13_227_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx207"},{"key":"e_1_2_13_228_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4223"},{"key":"e_1_2_13_229_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1502-y"},{"key":"e_1_2_13_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.03.021"},{"key":"e_1_2_13_231_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00530-9"},{"key":"e_1_2_13_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.01.018"},{"key":"e_1_2_13_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02247-2"},{"key":"e_1_2_13_234_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04480-3"},{"key":"e_1_2_13_235_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003738200"},{"key":"e_1_2_13_236_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04591"},{"key":"e_1_2_13_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2016.06.005"},{"key":"e_1_2_13_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216614"},{"key":"e_1_2_13_239_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-00978-2"},{"key":"e_1_2_13_240_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.TM118.001189"},{"key":"e_1_2_13_241_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709715200"},{"key":"e_1_2_13_242_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-05920-4"},{"key":"e_1_2_13_243_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201696394"},{"key":"e_1_2_13_244_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00903-1"},{"key":"e_1_2_13_245_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4093"},{"key":"e_1_2_13_246_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020105001"},{"key":"e_1_2_13_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.032"},{"key":"e_1_2_13_248_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.080218"},{"key":"e_1_2_13_249_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c00414"},{"key":"e_1_2_13_250_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42005-024-01875-4"},{"key":"e_1_2_13_251_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-39565-w"},{"key":"e_1_2_13_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2023.11.2989"},{"key":"e_1_2_13_253_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202113156"},{"key":"e_1_2_13_254_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c07591"},{"key":"e_1_2_13_255_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2023106"},{"key":"e_1_2_13_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.015"},{"key":"e_1_2_13_257_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2018.1512614"},{"key":"e_1_2_13_258_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12541"},{"key":"e_1_2_13_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.05.017"},{"key":"e_1_2_13_260_1","volume-title":"Global Cancer Burden Growing, Amidst Mounting Need for Services","author":"WHO","year":"2024"},{"key":"e_1_2_13_261_1","doi-asserted-by":"publisher","DOI":"10.1038\/38444"},{"key":"e_1_2_13_262_1","doi-asserted-by":"publisher","DOI":"10.1038\/13732"},{"key":"e_1_2_13_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.05.019"},{"key":"e_1_2_13_264_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.419945"},{"key":"e_1_2_13_265_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1982-9"},{"key":"e_1_2_13_266_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-020-0010-4"},{"key":"e_1_2_13_267_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-022-01067-3"},{"key":"e_1_2_13_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.03.066"},{"key":"e_1_2_13_269_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1426413"},{"key":"e_1_2_13_270_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.3c02356"},{"key":"e_1_2_13_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2020.09.023"},{"key":"e_1_2_13_272_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.751880"},{"key":"e_1_2_13_273_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2024.128026"},{"key":"e_1_2_13_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2024.06.014"},{"key":"e_1_2_13_275_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c08674"},{"key":"e_1_2_13_276_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2023028"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202501476R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T12:54:31Z","timestamp":1763124871000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202501476R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,5]]},"references-count":275,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,7,15]]}},"alternative-id":["10.1096\/fj.202501476R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202501476r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,5]]},"assertion":[{"value":"2025-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70773"}}