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However, the potential of OM\u2010MSCs\u2010EXOs to improve intracranial hemorrhage (ICH) and its underlying mechanisms is unclear. In this study, we found that OM\u2010MSCs\u2010EXOs can perfect neurofunctional recovery after ICH. The level of miR\u201030b\u20105p declined in thrombin\u2010triggered OM\u2010MSCs. Suppression of miR\u201030b\u20105p in OM\u2010MSCs\u2010EXOs inhibited mitophagy and promoted reactive oxygen species (ROS) and inflammasome\u2010related protein levels. Moreover, downregulation of miR\u201030b\u20105p in OM\u2010MSCs\u2010EXOs inhibited HT22 cell viability and promoted apoptosis and inflammation. Mechanistically, miR\u201030b\u20105p targeted SENP5 and decreased the level of SENP5. SENP5 silencing upregulated SUMO2\/3\u2010conjugated METTL3 and downregulated METTL3 levels. METTL3 silencing inhibited LPA1 levels by inhibiting m6A modifications. Further, SUMOylated METTL3 was decreased and the m6A level of LPA1 was enhanced in thrombin\u2010triggered BV2 cells, which was abolished by OM\u2010MSCs\u2010EXOs, and this phenomenon was reversed by miR\u201030b\u20105p silenced\u2010OM\u2010MSCs\u2010EXOs. This work confirmed the potential of OM\u2010MSCs\u2010EXOs mediated delivery of miR\u201030b\u20105p in relieving ICH via the SENP5\/METTL3\/LPA1 axis.<\/jats:p>","DOI":"10.1096\/fj.202501522rr","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T14:46:23Z","timestamp":1760021183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Olfactory Mucosa Mesenchymal Stem Cells (\n                    <scp>OM<\/scp>\n                    \u2010\n                    <scp>MSCs<\/scp>\n                    )\u2010Derived Exosomes Mitigate Neuroinflammation and Nerve Injury After Intracranial Hemorrhage (\n                    <scp>ICH<\/scp>\n                    ) Through\n                    <scp>miR<\/scp>\n                    \u201030\u20105p and Its Associated 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Medicine Central South University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine Central South University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangli","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine Central South University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-7311","authenticated-orcid":false,"given":"Zigui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine Central South University  Haikou Hainan 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