{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:36:14Z","timestamp":1787009774468,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic pancreatitis (CP) is characterized by progressive fibrosis and islet dysfunction, yet effective therapeutic strategies remain limited. This study elucidates the mechanism by which baicalin ameliorates CP progression through modulation of the interferon\u2010\u03b1\/\u03b2 receptor (IFNAR)\/janus kinase (JAK)\/signal transducer and activator of transcription (STAT) signaling pathway. In a caerulein\u2010induced CP rat model, baicalin treatment (100\u2009mg\/kg\/day, 6\u2009weeks) markedly reduced pancreatic injury, collagen deposition, and \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) expression, alongside decreased serum levels of IL\u20106, TNF\u2010\u03b1, TGF\u2010\u03b2, amylase, and lipase. Flow cytometry revealed that baicalin suppressed pancreatic infiltration of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, macrophages, and NK cells while elevating regulatory T (Treg) cell proportions. Transcriptomic analysis identified JAK\/STAT signaling as a key pathway inhibited by baicalin, with molecular docking confirming its direct binding to IFNAR. In\u00a0vitro, baicalin (10\u2009\u03bcM) attenuated TGF\u2010\u03b21\u2010activated pancreatic stellate cell (PSC) activation, evidenced by reduced lipid droplet loss and \u03b1\u2010SMA\/COL1A1 expression. Overexpression of IFNAR reversed baicalin's anti\u2010fibrotic effects, whereas co\u2010treatment with the JAK inhibitor ruxolitinib partially restored its efficacy. In\u00a0vivo, IFNAR overexpression diminished baicalin's therapeutic benefits, but ruxolitinib co\u2010administration mitigated pancreatic damage. These findings demonstrate that baicalin alleviates CP fibrosis and islet dysfunction by targeting IFNAR to suppress JAK\/STAT signaling, modulating immune cell dynamics, and inhibiting PSC activation. This study highlights IFNAR as a novel therapeutic target and positions baicalin as a promising candidate for CP treatment.\n                  <\/jats:p>","DOI":"10.1096\/fj.202501649r","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T10:42:02Z","timestamp":1757932922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Baicalin Alleviates Chronic Pancreatitis Fibrosis and Islet Dysfunction via Targeting\n                    <scp>IFNAR<\/scp>\n                    \u2010Mediated\n                    <scp>JAK<\/scp>\n                    \/\n                    <scp>STAT<\/scp>\n                    Signaling and Immune Modulation"],"prefix":"10.1096","volume":"39","author":[{"given":"Hehe","family":"Dou","sequence":"first","affiliation":[{"name":"Emergency Surgery Department The First Affiliated Hospital of Bengbu Medical College  Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Graduate Studies Bengbu Medical College  Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Graduate Studies Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Emergency Surgery Department The First Affiliated Hospital of Bengbu Medical College  Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Emergency Surgery Department The First Affiliated Hospital of Bengbu Medical College  Bengbu 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