{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:13:57Z","timestamp":1793142837812,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Previous studies have established a causal relationship between gut microbiota and acute pancreatitis (AP) using Mendelian randomization (MR) methods, with a predominant focus on European populations. This study aimed to systematically evaluate this association through meta\u2010analysis and bidirectional MR in East Asian populations. The meta\u2010analysis integrated data from 10 studies, revealing that gut dysbiosis significantly increased AP risk, with the \u201cother functional microbiota\u201d showing the most substantial effect. The MR analysis, utilizing large\u2010scale genome\u2010wide association study data, identified potential causal relationships between specific gut microbiota taxa and AP in both European and East Asian populations. Notably, specific taxa, such as\n                    <jats:italic>Olsenella<\/jats:italic>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Clostridium leptum<\/jats:italic>\n                    <\/jats:styled-content>\n                    , were associated with an increased AP risk, while\n                    <jats:italic>Odoribacter<\/jats:italic>\n                    exhibited protective effects. These findings support the potential for microbiota\u2010targeted interventions in AP and emphasize the consistency of the association between gut dysbiosis and AP risk across diverse populations.\n                  <\/jats:p>","DOI":"10.1096\/fj.202501787r","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T10:51:01Z","timestamp":1755773461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Towards Microbiota\u2010Targeted Interventions in Acute Pancreatitis: Evidence From Meta\u2010Analysis and Mendelian Randomization"],"prefix":"10.1096","volume":"39","author":[{"given":"Anqi","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery Yanbian University Affiliated Hospital  Yanji Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Yanbian University Affiliated Hospital  Yanji Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Yanbian University Affiliated Hospital  Yanji Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Wei","sequence":"additional","affiliation":[{"name":"Modern Education Technology Center Heze Medical College  Heze Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6461-6707","authenticated-orcid":false,"given":"Guanghua","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Yanbian University Affiliated Hospital  Yanji Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60649-8"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.20317"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-98532-9"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-03895-y"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-025-09084-x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002645"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.02.052"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14060642"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106954"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101559"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.755705"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.829426"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-024-00652-6"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-025-03313-x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114769"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36266-7"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-07948-8"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2022.11.011"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-00532-0"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-018-1464-9"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0350-x"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-024-01298-9"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-11493-y"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2024.101885"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-024-01327-7"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02761-6"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-04894-5"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-024-00553-y"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111850"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e42243"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1529-0"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00931-x"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.11952\/j.issn.1007\u20101954.2024.06.005"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3623"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2024.107030"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002861"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-024-02125-6"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037959"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038331"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1452743"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1290202"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16658"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.12.013"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i30.5019"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1380998"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2002.02044"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1379064"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1193-1"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c07635"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15980"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-024-00499-4"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-0375"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231202133"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021159"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201801419"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-72057-z"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202501787R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:17:37Z","timestamp":1761675457000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202501787R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":56,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8,31]]}},"alternative-id":["10.1096\/fj.202501787R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202501787r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"assertion":[{"value":"2025-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70938"}}