{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:50:36Z","timestamp":1791280236544,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102023\u201005099"],"award-info":[{"award-number":["RGPIN\u20102023\u201005099"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Iron overload drives oxidative stress and vascular injury, yet the role of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) in systemic and vascular iron regulation remains unclear. We investigated how cystathionine \u03b3\u2010lyase (CSE)\u2010derived H\n                    <jats:sub>2<\/jats:sub>\n                    S influences iron handling and vascular responses following acute iron overload. Wild\u2010type (WT) and CSE\u2010knockout (CSE\u2010KO) mice received PBS, low\u2010concentration (1\u00d7) or high\u2010concentration (3\u00d7) iron dextran intravenously. CSE\u2010KO mice exhibited elevated serum iron and transferrin saturation but impaired ferritin upregulation compared to WT. KO aortas showed greater iron deposition, elastin degradation, and inflammatory remodeling under high iron. Iron overload impaired phenylephrine\u2010induced vasocontraction and H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010mediated vasorelaxation, with CSE\u2010KO mice displaying the most severe vascular dysfunction and elevated blood pressure. WT mice compensated via CSE upregulation and increased H\n                    <jats:sub>2<\/jats:sub>\n                    S production. Our findings demonstrate that CSE\/H\n                    <jats:sub>2<\/jats:sub>\n                    S deficiency disrupts ferritin\u2010mediated iron storage, exacerbates vascular iron accumulation, and worsens vasomotor dysfunction during iron overload. The CSE\/H\n                    <jats:sub>2<\/jats:sub>\n                    S pathway may represent a therapeutic target for mitigating iron\u2010induced vascular damage.\n                  <\/jats:p>","DOI":"10.1096\/fj.202502763rr","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:24:12Z","timestamp":1761071052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CSE\u2010Derived Hydrogen Sulfide Safeguards Vascular Iron Homeostasis by Coupling Ferritin Buffering to Vasoprotection"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-4471","authenticated-orcid":false,"given":"Hassan Mustafa","family":"Arif","sequence":"first","affiliation":[{"name":"Department of Biology York University  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Biology York University  Toronto Ontario Canada"},{"name":"College of Basic Medicine Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Biology York University  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3825-3620","authenticated-orcid":false,"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biology York University  Toronto Ontario Canada"},{"name":"College of Basic Medicine Shandong Second Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0203"},{"key":"e_1_2_10_3_1","first-page":"51","article-title":"The Regulation of Iron Absorption and Homeostasis","volume":"37","author":"Wallace D. 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