{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T14:50:51Z","timestamp":1781967051855,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Rheumatoid arthritis\u2010associated interstitial lung disease (RA\u2010ILD) is a severe extra\u2010articular complication with limited treatment options. This study identified Glyasperin F, a flavonoid derived from licorice and dried ginger decoction, as a potent inhibitor of glycolytic reprogramming in RA\u2010ILD. Using a murine model combining collagen\u2010induced arthritis and bleomycin\u2010induced pulmonary fibrosis, we demonstrated that Glyasperin F significantly alleviated joint inflammation and pulmonary fibrosis. An in\u00a0vitro inflammatory\u2013fibrotic model was established by co\u2010stimulating MRC\u20105 human lung fibroblasts with TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 and IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    . This model was combined with pharmacological modulation of Sirt1 using EX527 and SRT1720, as well as HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    overexpression or empty\u2010vector lentiviral transduction, to dissect the underlying molecular mechanisms. Mechanistically, Glyasperin F upregulated Sirt1, thereby suppressing the PI3K\/Akt\/HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    pathway, downregulating key glycolytic enzymes (HK2, PFK, PKM2, LDHA), and reducing lactate\/ATP production and oxidative stress. HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    overexpression reversed these therapeutic effects. This study suggests that Glyasperin F has the potential to serve as a natural candidate compound for the regulation of glycolytic metabolism in the intervention of RA\u2010ILD.\n                  <\/jats:p>","DOI":"10.1096\/fj.202503559rr","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T10:53:28Z","timestamp":1780138408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Activation of Sirt1 by Glyasperin F Suppresses\n                    <scp>PI3K<\/scp>\n                    \/Akt\/\n                    <scp>HIF<\/scp>\n                    \u20101\u03b1 Signaling and Inhibits Glycolytic Metabolism to Ameliorate Pathology in Rheumatoid Arthritis\u2010Associated Interstitial Lung Disease"],"prefix":"10.1096","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6149-6626","authenticated-orcid":false,"given":"Hui","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Immunology and Hematology Affiliated Hospital of Shaanxi University of Chinese Medicine  Xianyang China"},{"name":"Department of Rheumatology Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Immunology and Hematology Affiliated Hospital of Shaanxi University of Chinese Medicine  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Medical Technology Shaanxi University of Chinese Medicine  Xianyang 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