{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:58:09Z","timestamp":1777946289296,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,1,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is an autoimmune disease with a strong genetic component. Although genome\u2010wide association studies (GWAS) have identified multiple risk loci, the underlying causal genes and biological mechanisms remain predominantly elusive. GWAS data for IBD, UC, and CD were obtained from the FinnGen R10 dataset and integrated with expression quantitative trait locus (eQTL) data from the Genotype\u2010Tissue Expression Project (GTEx) v8 to perform cross\u2010tissue transcriptome\u2010wide association studies (TWAS). Single\u2010tissue TWAS validation was conducted using Functional Summary\u2010based Imputation (FUSION). Multi\u2010marker Analysis of GenoMic Annotation (MAGMA), Mendelian randomization (MR), colocalization, and summary data\u2010based MR (SMR) analyses were applied to identify candidate susceptibility genes. GeneMANIA analysis was performed to explore functional implications. The same analytical framework was used on independent GWAS datasets to assess consistency. 6 susceptibility genes were identified for IBD, 1 for UC, and 2 for CD. These findings were supported by cross\u2010 and single\u2010tissue TWAS, MAGMA, MR, colocalization, and SMR analyses. In independent datasets, partial gene\u2010level concordance and substantial consistent pathway\u2010level signals were observed. GeneMANIA analyses suggested that susceptibility genes in IBD, UC, and CD were mainly associated with 3\u2032,5\u2032\u2010cyclic\u2010nucleotide phosphodiesterase activity, transition metal ion transmembrane transporter activity, and CENP\u2010A\u2013containing chromatin organization, respectively. By integrating cross\u2010tissue TWAS with multi\u2010tier validation strategies, this study provides new insights into the genetic architecture of IBD. Further functional studies are necessary to elucidate the mechanisms by which these candidate genes contribute to IBD pathogenesis.<\/jats:p>","DOI":"10.1096\/fj.202503572r","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:32:08Z","timestamp":1768897928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Cross\u2010Tissue Transcriptome\u2010Wide Association Study Reveals Novel Susceptibility Genes for Inflammatory Bowel Disease"],"prefix":"10.1096","volume":"40","author":[{"given":"Yang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Shengjing Hospital of China Medical University  Shenyang Liaoning Province 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