{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:28:01Z","timestamp":1786562881572,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203777"],"award-info":[{"award-number":["82203777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,3,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gastric cancer (GC) is a leading cause of cancer\u2010related deaths and has high recurrence rate. Although fibronectin domain\u2010containing protein 1 (FNDC1) is implicated in GC progression, its molecular mechanisms remain unclear. Multi\u2010omics analyses (TCGA, GEO datasets) were used to assess FNDC1 expression and clinical correlation. In\u00a0vitro (cell proliferation, invasion, EMT markers) and in\u00a0vivo (xenograft) experiments, combined with molecular assays (Co\u2010IP, WB, ChIP), explored FNDC1's function and mechanism. FNDC1 was significantly upregulated in GC, correlating with advanced clinicopathological features and poor prognosis. Knockdown of FNDC1 suppressed GC cell proliferation, invasion, and metastasis by inhibiting EMT and Wnt\/\u03b2\u2010catenin signaling. Mechanistically, FNDC1 competitively bound the WD5 domain (residues 224\u2013254) of G\u03b22, disrupting G\u03b2\u03b3\u2013Dvl1 interaction. This prevented Dvl1 degradation, promoted Axin1 ubiquitination, and destabilized the \u03b2\u2010catenin\u2013destruction complex (GSK3 \u03b2\u2013APC\u2013Axin1), leading to \u03b2\u2010catenin accumulation and Wnt pathway activation. FNDC1 drives GC malignancy by targeting the G\u03b22\u2013Dvl1 axis to activate Wnt\/\u03b2\u2010catenin signaling, suggesting FNDC1 as a novel prognostic biomarker and therapeutic target.<\/jats:p>","DOI":"10.1096\/fj.202503587r","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:39:46Z","timestamp":1773211186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>FNDC1<\/scp>\n                    Competitively Binds G\u03b22 to Suppress the \u03b2\u2010Catenin\u2013Destruction Complex and Promote Gastric Cancer Malignancy"],"prefix":"10.1096","volume":"40","author":[{"given":"Wenyu","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Fujian Medical University Union Hospital  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Union Hospital  Fuzhou People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Translational Cancer Medicine  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Union Hospital  Fuzhou People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Translational Cancer Medicine  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Union Hospital  Fuzhou People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Translational Cancer Medicine  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fujian Medical University Union Hospital  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Union Hospital  Fuzhou People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Translational Cancer Medicine  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiao","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Union Hospital  Fuzhou People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Translational Cancer Medicine  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Union Hospital  Fuzhou People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Translational Cancer Medicine  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6930-7778","authenticated-orcid":false,"given":"Xiaoyan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Union Hospital  Fuzhou People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Translational Cancer Medicine  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Union Hospital  Fuzhou People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Translational Cancer Medicine  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(19)30328\u20100"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2024.03.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102024\u2010333617"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201050171\u20107"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5812-9_2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.09.021"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906\u20106705.2005.00349.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25818"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6731"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.27672"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533033819869928"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00166.2021"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202011987"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507467103"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22376"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14048"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010020\u201000990\u20103"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.013540"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S110203"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010010\u20109766\u2010y"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3850"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.052"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12064\u2010012\u20100162\u20103"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001563\u20104"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407681"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201006302\u20100"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2009.41.10.076"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)31288\u20105"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102024\u2010332705"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010023\u201001451\u20103"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103841"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218989"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13235901"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12118"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.181883"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115973"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15055"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.12.001"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101511"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2024.07.009"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010024\u201002064\u20101"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010023\u201001793\u2010z"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/gch2.202100094"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010022\u201001347\u20108"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010022\u201001569\u2010x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010022\u201001747\u20100"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.10.047"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI154515"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010018\u20100497\u20104"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201012203\u20108"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202050600"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010024\u201001011\u20100"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04\u20102373fje"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107534"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202503587R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202503587R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202503587R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:36:51Z","timestamp":1786559811000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202503587R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3,31]]}},"alternative-id":["10.1096\/fj.202503587R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202503587r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]},"assertion":[{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71634"}}