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SIRT1 has been implicated in various biological processes, but its specific role in regulating immune responses during\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infection remains inadequately defined. Our study shows that SIRT1 promotes\n                    <jats:italic>Salmonella<\/jats:italic>\n                    invasion of host cells, and its inhibition impairs intracellular bacterial survival in macrophages. SIRT1 suppresses the secretion of immune factors and attenuates the innate immune response of the host by regulating the NF\u2010\u03baB signaling pathway. Using RNA\u2010Seq, we found that SIRT1 plays a crucial role in host immune responses by modulating pathogen\u2010associated molecular pattern recognition via membrane\u2010bound (TLR\u2010like) and intracellular (NLR\u2010like). Acetylomic analysis revealed that SIRT1 inhibition primarily affects acetylation within metabolic and transcriptional networks. Furthermore, inhibition of SIRT1 activity enhanced the resistance of chicks to\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infection. In summary, our study indicates that SIRT1 promotes\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infection of chicken macrophages and weakens host defense by negatively regulating NF\u2010\u03baB activation and the production of proinflammatory cytokines.\n                  <\/jats:p>","DOI":"10.1096\/fj.202503595r","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:54:56Z","timestamp":1777107296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SIRT1<\/scp>\n                    Attenuates Host Resistance to\n                    <i>Salmonella<\/i>\n                    Infection by Negatively Regulating the Immune Responses"],"prefix":"10.1096","volume":"40","author":[{"given":"Sha","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding Institute of Animal Sciences, Chinese Academy of 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