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In this study, we demonstrated that chronic toxoplasmosis induced depression\u2010like behaviors in mice, which were observed together with neuroinflammation, neuronal injury, and suppression of the BDNF\u2013TrkB pathway. Treatment with the TrkB agonist 7,8\u2010DHF alleviated these behavioral deficits by restoring BDNF\u2013TrkB signaling, preserving neuronal function, and reducing neuroinflammation through inhibition of NF\u2010\u03baB and MAPK pathways. Additionally, 7,8\u2010DHF also reduced astrocyte overactivation and protected blood\u2013brain barrier structure integrity. These findings highlight that disruption of BDNF\u2013TrkB signaling contributes to\n                    <jats:italic>T. gondii<\/jats:italic>\n                    \u2010induced behavioral abnormalities and that targeting this pathway may represent a promising therapeutic strategy against neuroinflammation and neuronal damage associated with chronic infection.\n                  <\/jats:p>","DOI":"10.1096\/fj.202503699rr","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:40:15Z","timestamp":1773157215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["7, 8\u2010Dihydroxyflavone Ameliorates Depression\u2010Like Behaviors in Mice Induced by\n                    <i>Toxoplasma gondii<\/i>\n                    via the\n                    <scp>BDNF<\/scp>\n                    \u2013\n                    <scp>TrkB<\/scp>\n                    Signaling Pathway"],"prefix":"10.1096","volume":"40","author":[{"given":"Wen\u2010Qian","family":"Shi","sequence":"first","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine Yangzhou University, and Jiangsu Co\u2010Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, and Jiangsu Key Laboratory of Zoonosis  Yangzhou People's Republic of China"},{"name":"Chongqing Academy of Animal Sciences  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqiong","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangzhou Customs District Technology Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Yuan","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine Yangzhou University, and Jiangsu Co\u2010Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, and Jiangsu Key Laboratory of Zoonosis  Yangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8129-3145","authenticated-orcid":false,"given":"Ming","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine Yangzhou University, and Jiangsu Co\u2010Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, and Jiangsu Key Laboratory of Zoonosis  Yangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Feng","family":"Hou","sequence":"additional","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine Yangzhou University, and Jiangsu Co\u2010Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, and Jiangsu Key Laboratory of Zoonosis  Yangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1452-1299","authenticated-orcid":false,"given":"Si\u2010Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Comparative Medicine, College of Veterinary Medicine Yangzhou University, and Jiangsu Co\u2010Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, and Jiangsu Key Laboratory of Zoonosis  Yangzhou People's Republic of China"},{"name":"Chongqing Academy of Animal Sciences  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/2327-6924.12129"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0323126"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.12.009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02330-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.01.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.04.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed10010018"},{"key":"e_1_2_10_9_1","unstructured":"L.Tan P. 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