{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:18:43Z","timestamp":1788167923950,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["222300420346"],"award-info":[{"award-number":["222300420346"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The oxidative phosphorylation diffuse large B\u2010cell lymphoma (Oxphos DLBCL) subtype is characterized by increased oxidative phosphorylation, but the mechanism underlying energy metabolism in Oxphos DLBCL cells is not well understood. Here, we first confirmed that oxysterol\u2010binding protein\u2010related protein 10 (ORP10) was highly expressed in Oxphos DLBCL cells tested and that\n                    <jats:italic>ORP10<\/jats:italic>\n                    knockdown clearly inhibited Oxphos DLBCL cell tested proliferation in\u00a0vitro and in\u00a0vivo, and increased cell death. After screening interacting proteins, we found that\n                    <jats:italic>ORP10<\/jats:italic>\n                    directly interacted with inositol 1,4,5\u2010trisphosphate (IP\n                    <jats:sub>3<\/jats:sub>\n                    ) receptor 1 (IP\n                    <jats:sub>3<\/jats:sub>\n                    R1), and that\n                    <jats:italic>ORP10<\/jats:italic>\n                    knockdown reduced cytosolic and mitochondrial parallel Ca\n                    <jats:sup>2+<\/jats:sup>\n                    spike oscillations, the oxygen consumption rate (OCR), and intracellular ATP levels, but had no impact on lactic acid production. In addition,\n                    <jats:italic>ORP10<\/jats:italic>\n                    knockdown enhanced autophagic cell death in Oxphos DLBCL cells tested. These data support a novel model in which\n                    <jats:italic>ORP10<\/jats:italic>\n                    associates with IP\n                    <jats:sub>3<\/jats:sub>\n                    R1 and is required for robust IP\n                    <jats:sub>3<\/jats:sub>\n                    R1\u2010dependent Ca\n                    <jats:sup>2+<\/jats:sup>\n                    responses, which maintain mitochondrial energetics in Oxphos DLBCL cells tested. Thus,\n                    <jats:italic>ORP10<\/jats:italic>\n                    may represent a promising metabolic vulnerability marker of Oxphos DLBCL cells tested.\n                  <\/jats:p>","DOI":"10.1096\/fj.202504497r","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:45:03Z","timestamp":1777106703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ORP10 Maintains Mitochondrial Energy Metabolism by Modulating\n                    <scp>BCR<\/scp>\n                    \u2010Evoked Ca\n                    <sup>2+<\/sup>\n                    Signaling in Diffuse Large B\u2010Cell Lymphoma Cells"],"prefix":"10.1096","volume":"40","author":[{"given":"Jieke","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhengzhou University  Zhengzhou 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