{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:56:20Z","timestamp":1787806580686,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330017"],"award-info":[{"award-number":["82330017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270610"],"award-info":[{"award-number":["82270610"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0530100"],"award-info":[{"award-number":["2024ZD0530100"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20240484505"],"award-info":[{"award-number":["20240484505"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,5,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute pancreatitis (AP) is an inflammatory disorder with no efficient therapy. Here we demonstrate that the anorexigenic peptide nesfatin\u20101 exerts potent and dose\u2010dependent protection against both caerulein\u2010induced and hypertriglyceridemic AP. Intraperitoneal administration of nesfatin\u20101 to restore its serum levels significantly reduced pancreatic necrosis, edema, and infiltration of immune cells, as well as circulating levels of amylase, lipase, and pro\u2010inflammatory cytokines. RNA\u2010seq revealed that nesfatin\u20101 down\u2010regulated the ER\u2010stress signature (\n                    <jats:italic>Ddit3<\/jats:italic>\n                    ,\n                    <jats:italic>Atf3<\/jats:italic>\n                    ,\n                    <jats:italic>Ppp1r15a<\/jats:italic>\n                    ) and the NF\u2010\u03baB\/NLRP3 signaling. Further studies in primary acinar cells confirmed that nesfatin\u20101 at the dose of 10\u2009nM suppressed phosphorylated eIF2\u03b1, DDIT3, ATF3, p65, and NLRP3, thereby inhibiting pyroptosis. Consequently, nesfatin\u20101 attenuated macrophage\/neutrophil infiltration, shifted M1 toward M2 macrophages, inhibited the release of inflammatory cytokines, and alleviated multi\u2010organ injury in lung, intestine, and spleen. Collectively, nesfatin\u20101 limits AP severity by restraining ER\u2010stress\u2010driven pyroptosis and innate immune activation. Thus, nesfatin\u20101 may serve as a promising therapeutic candidate for acute pancreatitis.\n                  <\/jats:p>","DOI":"10.1096\/fj.202504662rr","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:01:15Z","timestamp":1779364875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nesfatin\u20101 Ameliorates Acute Pancreatitis by Inhibiting the Pyroptosis of Acinar Cells and Inflammation Mediated by Macrophages and Neutrophils"],"prefix":"10.1096","volume":"40","author":[{"given":"Han","family":"Li","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences, and State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences, and State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefeng","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences, and State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology School of Basic Medical Sciences, and State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinmo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University First Hospital  Beijing 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