{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:47:05Z","timestamp":1791809225049,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH_D_114127"],"award-info":[{"award-number":["TSGH_D_114127"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A novel gold nanoparticle\u2010chitosan (AuNP@chitosan) composite is introduced as a potent biointerface modulator for burn trauma care. In this study, the unique interfacial characteristics of the composite are linked to its therapeutic activity, and its effects on endothelial function and immune response in severe bleeding and inflammatory models are examined. AuNP@chitosan synthesis was verified using FTIR and fluorescence, and its effects were assessed in TNF\u2010\u03b1\u2010induced HUVECs, LPS\u2010stimulated macrophages, and an animal model. In\u00a0vitro, AuNP@chitosan protects TNF\u2010\u03b1\u2010injured human endothelial cells (HUVECs) by restoring thrombomodulin expression, reducing ROS, and relieving the upregulated hypoxia\u2010adaptive markers (HIF\u20101\u03b1 and fibronectin). Concurrently, in LPS\u2010stimulated RAW 264.7 macrophages, it suppresses pro\u2010inflammatory mediators (TNF\u2010\u03b1 and IL\u20106) while preserving COX\u20101 and enhancing IL\u201010 production. These cell\u2010specific responses reflect distinct but complementary mechanisms, vascular protection and immune regulation, which were further validated in a rat burn model. In\u00a0vivo application of AuNP@chitosan dressings significantly reduced infiltration of CD4\n                    <jats:sup>+<\/jats:sup>\n                    , CD8\n                    <jats:sup>+<\/jats:sup>\n                    , and CD68\n                    <jats:sup>+<\/jats:sup>\n                    immune cells in wound tissue, supporting the translational relevance of the dual in\u00a0vitro findings. The integrated cell and animal studies demonstrate that AuNP@chitosan acts via redox and immune modulation to promote a pro\u2010healing wound environment.\n                  <\/jats:p>","DOI":"10.1096\/fj.202504913rr","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:57:20Z","timestamp":1790351840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Oxidative and Immune Dysregulation in Wound Healing via Gold Nanoparticle Conjugate Chitosan"],"prefix":"10.1096","volume":"40","author":[{"given":"Sheng\u2010Der","family":"Hsu","sequence":"first","affiliation":[{"name":"Division of Traumatology, Department of Surgery, Tri\u2010Service General Hospital National Defense Medical University  Taipei Taiwan (ROC)"},{"name":"Division of General Surgery, Department of Surgery Zuoying Armed Forces General Hospital  Kaohsiung Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department and Graduate Institute of Biology and Anatomy, College of Medicine National Defense Medical University  Taipei Taiwan (ROC)"},{"name":"Laboratory of Stem Cell and Tissue Regeneration National Defense Medical University  Taipei Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010An","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Chung Yuan Christian University  Taoyuan Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang\u2010Yi","family":"Fan","sequence":"additional","affiliation":[{"name":"Department and Graduate Institute of Biology and Anatomy, College of Medicine National Defense Medical University  Taipei Taiwan (ROC)"},{"name":"Laboratory of Stem Cell and Tissue Regeneration National Defense Medical 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