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It is increasingly evident that interorgan neuroimmune crosstalk in adipose tissue maintains adipose tissue functionality, yet the molecular mechanisms are incompletely understood. The vagus nerve regulates numerous physiological functions, including inflammation and weight control, even in tissues lacking direct cholinergic innervation. In this study, we examined whether vagal signaling is involved in maintaining baseline homeostasis in epididymal white adipose tissue (eWAT) by investigating how disrupting vagus signaling affects adipose tissue physiology. As expected, vagotomized male animals had lower body weight and epididymal white adipose tissue mass as compared with controls. Vagotomized animals showed increased Ly6G\n                    <jats:sup>+<\/jats:sup>\n                    cell infiltration in eWAT. Interestingly, vagotomy\u2010associated weight loss was significantly attenuated in neutrophil\u2010deficient Ly6G\n                    <jats:sup>cre<\/jats:sup>\n                    Mcl1\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    mice and in mice treated with repeated injections of anti\u2010Ly6G antibodies. Together, these observations indicate that there is a Ly6G\u2010mediated vagotomy\u2010associated reduction in weight and reveal that Ly6G\n                    <jats:sup>+<\/jats:sup>\n                    cells participate in the regulation of eWAT energy homeostasis.\n                  <\/jats:p>","DOI":"10.1096\/fj.202600151rr","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T11:35:00Z","timestamp":1775302500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphocyte Antigen\n                    <scp>6G<\/scp>\n                    Mediates Vagotomy\u2010Associated Reduction in Body Weight"],"prefix":"10.1096","volume":"40","author":[{"given":"Ting","family":"Liu","sequence":"first","affiliation":[{"name":"Laboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine 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