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However, poor prognosis patients and drug\u2010resistant cells exhibit constitutively elevated levels of FOXK2 protein, which appears functionally inactive. Although emerging evidence suggests that FOXK2 is regulated by post\u2010translational modifications, the underlying mechanisms in breast cancer remain poorly understood. An\n                    <jats:italic>in silico<\/jats:italic>\n                    analysis identified AKT as a putative regulator of FOXK2, prompting the investigation of AKT\u2010mediated phosphorylation of FOXK2 in cancer. Our results show that elevated FOXK2 protein levels are associated with increased AKT phosphorylation and doxorubicin resistance. Modulation of AKT levels reduces FOXK2 at protein but not mRNA levels. Consistently, analysis of public breast tumor datasets revealed increased FOXK2 phosphorylation at different sites, including serine 398. 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