{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:01:33Z","timestamp":1784818893487,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fasting, as a non\u2010pharmacological intervention, elicits antidepressant\u2010like effects. However, its neural and molecular mechanisms remain unclear. This study investigated whether intermittent fasting (IF) alleviates corticosterone (CORT)\u2010induced depressive\u2010like behaviors in mice and explored the underlying mechanisms. This study demonstrated that IF reversed the CORT\u2010induced reduction in hypothalamic glucocorticoid and mineralocorticoid receptor (GR\/MR) expression in mice. In addition, IF reversed a CORT\u2010induced decrease in arcuate nucleus (ARC) AgRP\/NPY neuronal activity and NPY output from these neurons while concurrently suppressing the activity of neighboring POMC neurons. This rebalanced ARC output attenuated paraventricular nucleus (PVN) hyperactivity, as evidenced by reduced c\u2010fos and increased NPY immunoreactivity. Remarkably, co\u2010administration of GR and MR antagonists (RU486 and spironolactone) abolished both the behavioral benefits and hypothalamic neuropeptidergic and activity changes induced by IF. Together, these findings identify a mechanism involving GR\/MR signaling through which IF alleviates depressive\u2010like states by rescuing the functional output of AgRP\/NPY\n                    <jats:sup>ARC<\/jats:sup>\n                    neurons from a state of activity\u2010output dissociation, thereby restoring HPA axis homeostasis.\n                  <\/jats:p>","DOI":"10.1096\/fj.202600451r","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:52:28Z","timestamp":1783410748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intermittent Fasting Exerts Antidepressant\u2010Like Effects by Restoring\n                    <scp>HPA<\/scp>\n                    Axis Homeostasis Through Coordinated\n                    <scp>GR<\/scp>\n                    \u2013\n                    <scp>MR<\/scp>\n                    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