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However, the role of its active form, ChREBP\u2010\u03b2, was previously unclear. In this study, ChREBP\u2010\u03b2 overexpression and ChREBP knockout mouse models were utilized to investigate the effects of excessive fructose intake in\u00a0vivo. In addition, primary renal tubular epithelial cells from mice and human kidney\u20102 (HK2) cells were applied for further validation in\u00a0vitro. We found that ChREBP\u2010\u03b2 leads to increased transcription to mediate endoplasmic reticulum stress and mitochondrial dysfunction, which ultimately impairs renal function. Our findings underscore the critical role of ChREBP\u2010\u03b2 in fructose\u2010related renal disorders.<\/jats:p>","DOI":"10.1096\/fj.202600490r","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:50:46Z","timestamp":1776091846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ChREBP<\/scp>\n                    \u2010\u03b2 Exacerbates Renal Tubular Disorders Caused by Fructose via\n                    <scp>ATF4<\/scp>"],"prefix":"10.1096","volume":"40","author":[{"given":"Ting","family":"Fang","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien\u2010I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University  Tianjin China"},{"name":"Department of Endocrinology The First Affiliated Hospital of Zhejiang Chinese Medical 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