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BAT is highly innervated with sensory and sympathetic nerve fibers. There is existing literature that sympathetic nerves have a critical role in regulating menthol's (or cold) effect on energy homeostasis, but there is minimal literature about the involvement of somatosensory innervations. Here, we ought to investigate whether short\u2010term topical application (3\u2009days) of menthol elicits sympathetic and sensory nerves. We used chemical denervation models of complete (100\u2009mg\/kg; 6\u2010OHDA and 125\u2009mg\/kg; capsaicin, s.c.) and localized (in BAT, 20\u2009\u03bcL of 6\u2010OHDA (20\u2009mg\/mL) and 20\u2009\u03bcL of capsaicin (20\u2009\u03bcg\/\u03bcL) in each BAT lobe) ablation of sympathetic (6\u2010OHDA) and sensory (capsaicin) innervations to explore their roles in menthol induced BAT activation and energy expanding phenotype. In the present study we have shown that (i) short\u2010term topical application of menthol (10% menthol for 3 consecutive days) elicits sympathetic and sensory innervations, and induces thermogenesis, lipolysis and mitochondrial biogenesis in mice BAT; (ii) localized ablation of sympathetic innervation prevented menthol induced BAT activation and lipolysis (iii) localized ablation of sensory neurons augments sympathetic innervations induced BAT activation and modulated thermoregulation. Collectively, our findings indicate that the sympathetic nervous system plays a major role in BAT activation following short\u2010term topical menthol application. Furthermore, sensory neurons contribute partially to this effect.<\/jats:p>","DOI":"10.1096\/fj.202600519rrrr","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:39:13Z","timestamp":1779784753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of Brown Adipose Tissue\u2010Specific Sympathetic and Sensory Innervations in Menthol\u2010Induced Energy\u2010Expending Phenotype"],"prefix":"10.1096","volume":"40","author":[{"given":"Roshan","family":"Lal","sequence":"first","affiliation":[{"name":"TR(i)P for Health Laboratory, Centre for Excellence in Functional Foods, Department of Food and Nutritional Biotechnology BRIC\u2010National Agri\u2010Food &amp; Biomanufacturing Institute (NABI) (Formerly\u2010 National Agri\u2010Food Biotechnology Institute)  SAS Nagar Punjab India"},{"name":"University Institute of Pharmaceutical Sciences Panjab University  Chandigarh 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