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Several reports indicate that N\u2010glycosylation of FGFR1 is critical for the FGFR1 trafficking to the cell surface, as glycosylation\u2010deficient mutant of FGFR1 (FGFR1.GF) is trapped inside the cell, in the endoplasmic reticulum (ER), and in the nuclear envelope. Our recent mass spectrometry analyses revealed dehydrogenase\/reductase 2 (DHRS2) as a putative binding partner of the intracellular FGFR1.GF. Here, we identified a peroxisomal targeting signal 1 (PTS1) at the C\u2010terminus of DHRS2 and demonstrated that DHRS2 is dually targeted to peroxisomes and mitochondria. Furthermore, we determined that knockdown of DHRS2 results in increased number of peroxisomes, implicating the role of DHRS2 in peroxisome biogenesis. Using proximity ligation assay (PLA), we confirmed the interaction between FGFR1.GF and DHRS2 and demonstrated that FGFR1.GF\/DHRS2 complexes are predominantly detected in peroxisomes. In agreement, we detected a small fraction of FGFR1.GF in peroxisomes. Taken together our data indicate that accumulation of FGFR1.GF in the ER may result in FGFR1.GF targeting to peroxisomes. Furthermore, we reveal interconnection between FGFR1 and DHRS2 and their role in peroxisome biogenesis.<\/jats:p>","DOI":"10.1096\/fj.202600529rr","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:58:25Z","timestamp":1782925105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blockade of\n                    <scp>FGFR<\/scp>\n                    1 Trafficking to the Cell Surface Results in the Partial Mistargeting of the Receptor to Peroxisomes"],"prefix":"10.1096","volume":"40","author":[{"given":"Paulina","family":"Dzia\u0142ek","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology, Faculty of Biotechnology University of Wroclaw  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Chor\u0105\u017cewska","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Faculty of 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