{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:07:59Z","timestamp":1783033679257,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472472"],"award-info":[{"award-number":["82472472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402873"],"award-info":[{"award-number":["82402873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302732"],"award-info":[{"award-number":["82302732"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ23H060002"],"award-info":[{"award-number":["LZ23H060002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023564481"],"award-info":[{"award-number":["2023564481"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,5,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Bone homeostasis is maintained by a dynamic balance between bone formation and resorption. Here, we link lipid metabolism to osteoclast differentiation by identifying stearoyl\u2010CoA desaturase\u20101 (SCD1) as a key regulatory factor. Notably, SCD1 expression was significantly upregulated during osteoclast differentiation, and knockdown of SCD1 or inhibiting its activity with A939572 significantly impaired osteoclast formation. Integrating RNA sequencing and metabolomics, we revealed that SCD1 inhibition altered arachidonic acid metabolism and influenced mitochondrial homeostasis. Mechanistically, A939572 upregulated COX1 and HPGDS expression, leading to the accumulation of Prostaglandin D2 (PGD2), which in turn suppressed osteoclast differentiation. Finally, we engineered a biomimetic nanovesicle (POCM\u2010NP@A939572) coated with preosteoclast membrane for targeted delivery. In\u00a0vivo, POCM\u2010NP@A939572 exhibited superior efficacy in preventing bone loss compared to A939572 alone. Collectively, this study demonstrates the SCD1\u2010COX1\u2010PGD2 axis as a therapeutic target and demonstrates the value of targeted nanomedicine in managing bone diseases.<\/jats:p>","DOI":"10.1096\/fj.202600672r","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:48:43Z","timestamp":1778687323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>SCD1<\/scp>\n                    Regulates Osteoclast Differentiation by Modulating Arachidonic Acid Metabolism and Mitochondrial Homeostasis"],"prefix":"10.1096","volume":"40","author":[{"given":"Yihao","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases  Hangzhou China"},{"name":"Department of Orthopedics Ningbo No. 2 Hospital  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine Hangzhou City University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Wound Healing The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qize","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Wound Healing The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases  Hangzhou China"},{"name":"Department of Wound Healing The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengdong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases  Hangzhou China"},{"name":"School of Medicine Hangzhou City University  Hangzhou China"},{"name":"Department of Wound Healing The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/421746"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1593"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411910020030601"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/79676"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1986.tb02220.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010022\u201000793\u20105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010021\u201002067\u20106"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.06.019"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.42.85"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.08.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.12.011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2022.06.024"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115586"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010023\u201001011\u20102"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2023.03.003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038581\u20108"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.08.034"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1976"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.02.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R068072"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28114316"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(10)62349\u20105"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(17)30188\u20102"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.07.019"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202115373"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg8982"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010024\u201000316\u2010w"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201008097\u20107"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01292"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.135"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.516716"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmr\/zjae034"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010022\u201001017\u20103"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774\u2010015\u20100656\u20104"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.70194"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202600672R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202600672R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202600672R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:17:37Z","timestamp":1781079457000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202600672R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,5,31]]}},"alternative-id":["10.1096\/fj.202600672R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202600672r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"2026-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71884"}}