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This study explores the therapeutic effects of linalool, a natural compound with antioxidant and anti\u2010inflammatory properties, on EMS in a rat model. Twenty\u2010four female rats were divided into four groups: sham, EMS control, and two treatment groups receiving linalool at 50\u2009mg\/kg and 100\u2009mg\/kg. EMS was induced by implanting uterine tissue, and linalool was administered for 28\u2009days. Oxidative stress markers (MDA, SOD, GPx, CAT), inflammation indicators (TNF\u2010\u03b1, IL\u20101\u03b2, NF\u2010\u03baB), apoptosis regulators (Bax, Bcl\u20102, caspase\u20103), autophagy marker (Beclin1), adhesion molecule (ICAM\u20101), and angiogenic factor (VEGF) were all assessed using biochemical and histological techniques. Linalool treatment significantly reduced lesion size and oxidative stress in a dose\u2010dependent manner. The higher dose group (Lina 100) showed nearly normal histological features tissue histology. Linalool boosted antioxidant enzymes, reduced inflammatory signaling via NF\u2010\u03baB and MAPK pathways, promoted apoptosis, and suppressed angiogenesis and cellular adhesion. These findings suggest that linalool exerts multi\u2010targeted effects to reduce EMS severity. The study highlights linalool's promise as a potential therapeutic agent for EMS, though further research in human models is needed to confirm its clinical relevance.<\/jats:p>","DOI":"10.1096\/fj.202600831r","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:45:39Z","timestamp":1788878739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Potential of Linalool in Endometriosis: Modulation of Oxidative Stress, Inflammation, and Apoptosis in a Rat Model"],"prefix":"10.1096","volume":"40","author":[{"given":"Reza","family":"Tadayonfar","sequence":"first","affiliation":[{"name":"Doctor of Veterinary Medicine Graduate, Faculty of Veterinary Medicine Lorestan University  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Doctor of Veterinary Medicine Graduate, 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